The 2021 season was North West Thunder's second season, in which they competed in the 50 over Rachael Heyhoe Flint Trophy and the new Twenty20 competition, the Charlotte Edwards Cup. The side finished seventh in the group stage of the Rachael Heyhoe Flint Trophy, winning three of their seven matches. In the Charlotte Edwards Cup, the side finished third in Group B, winning two of their six matches, with one ending in a tie.