The 2022–23 SFA South Region Challenge Cup is the 16th edition of the annual knockout cup competition for senior non-league clubs in the central and southern regions of Scotland. The tournament entry increased from 161 to a record 163 teams thanks to additional clubs joining the West of Scotland Football League. The competition is named the Traderadiators.com South Challenge Cup for sponsorship reasons. The defending champions are Auchinleck Talbot of the West of Scotland League, who beat Lowland League champions Bonnyrigg Rose Athletic 3–1 in the final on 22 May 2022.