The 2022 Illinois State Redbirds football team represented Illinois State University as a member of the Missouri Valley Football Conference (MVFC) during the 2022 NCAA Division I FCS football season. Led 14th-year head coach Brock Spack, the Redbirds compiled an overall record of 6–5 with a mark of 4–4 in conference play, tying for sixth place in the MVFC. Illinois State played home games at Hancock Stadium in Normal, Illinois.