Wesley Koolhof and Neal Skupski defeated Juan Sebastián Cabal and Robert Farah in the final, 6–7(4–7), 6–4, [10–5] to win the men's doubles tennis title at the 2022 Madrid Open. It was their first ATP Masters 1000 title. Marcel Granollers and Horacio Zeballos were the defending champions, but lost in the quarterfinals to Cabal and Farah. This tournament marked the final professional appearance of former doubles world No. 3 and Olympic gold medalist Marc López.