The 2022 Pennzoil 400 presented by Jiffy Lube was the third stock car race of the 2022 NASCAR Cup Series and the 25th running of the event. The race was held on Sunday, March 6, 2022, in North Las Vegas, Nevada at Las Vegas Motor Speedway, a 1.5 miles (2.4 km) permanent D-shaped oval racetrack. The race was extended from its scheduled 267 laps to 274 due to a NASCAR overtime caused by a crash including Erik Jones and Bubba Wallace. At race's end, Alex Bowman, driving for Hendrick Motorsports, would manage to climb to the front on the final restart and held off fellow teammate and eventual second-place finisher Kyle Larson to win his seventh career NASCAR Cup Series win and his first of the season. To fill out the top 3, Ross Chastain of the Trackhouse Racing Team would finish third.