The 2022 Ruoff Mortgage 500 was the fourth stock car race of the 2022 NASCAR Cup Series and the 18th running of the event. The race was held on Sunday, March 13, 2022, in Avondale, Arizona at Phoenix Raceway, a 1 mile (1.6 km) permanent low-banked tri-oval race track. The race took the scheduled 312 laps to complete. At race's end, Chase Briscoe, driving for Stewart-Haas Racing, pulled away on the final restart with three laps to go to capture his first career NASCAR Cup Series win and his first of the season. To fill out the top 3, Ross Chastain of the Trackhouse Racing Team and Tyler Reddick of Richard Childress Racing would finish second and third, respectively.