The 2022 Syracuse Orange football team represent Syracuse University during the 2022 NCAA Division I FBS football season. The Orange are led by seventh-year head coach Dino Babers and play their home games at the JMA Wireless Dome, competing as members of the Atlantic Coast Conference. The Orange started the season 6–0 for the first time since their undefeated 1987 season, before losing a close week seven matchup against the Clemson Tigers at Death Valley.