The 2022 United States Senate election in Missouri was held on November 8, 2022, concurrently with elections for all other Class 3 U.S. senators and elections for the U.S. House of Representatives, to select a member of the United States Senate to represent the state of Missouri. Incumbent Republican Senator Roy Blunt announced that he would not seek reelection to a third term in office. Missouri Attorney General Eric Schmitt won the election to succeed him.