About: 4-O-Methylhonokiol

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4-O-Methylhonokiol is a neolignan, a type of phenolic compound. It is found in the bark of Magnolia grandiflora and in M. virginiana flowers. 4-O-Methylhonokiol is a CB2 receptor ligand (Ki = 50 nM), showing inverse agonism and partial agonism via different pathways (cAMP and Ca2+), which potently inhibits osteoclastogenesis. 4-O-Methylhonokiol further attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway. The different neuroprotective effects reported in rodent models may be mediated via CB2 receptors. 4-O-Methylhonokiol activates CB2 receptors and also inhibits the oxygenation of the major endocannabinoid 2-AG via COX-2 in a substrate-selective manner, thus leading to potential synergistic effects

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rdf:type	Thing dul:ChemicalObject chemical substance Chemical compound yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Communication100033020 yago:Formula106816935 yago:Message106598915 yago:MolecularFormula106817173 chemical compound yago:Statement106722453
rdfs:label	4-O-Methylhonokiol (en)
rdfs:comment	4-O-Methylhonokiol is a neolignan, a type of phenolic compound. It is found in the bark of Magnolia grandiflora and in M. virginiana flowers. 4-O-Methylhonokiol is a CB2 receptor ligand (Ki = 50 nM), showing inverse agonism and partial agonism via different pathways (cAMP and Ca2+), which potently inhibits osteoclastogenesis. 4-O-Methylhonokiol further attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway. The different neuroprotective effects reported in rodent models may be mediated via CB2 receptors. 4-O-Methylhonokiol activates CB2 receptors and also inhibits the oxygenation of the major endocannabinoid 2-AG via COX-2 in a substrate-selective manner, thus leading to potential synergistic effects (en)
foaf:name	4-O-Methylhonokiol (en)
name	4 (xsd:integer)
foaf:depiction
dct:subject	Cannabinoids GABAA receptor positive allosteric modulators Lignans
Wikipage page ID	37241492 (xsd:integer)
Wikipage revision ID	1106656022 (xsd:integer)
Link from a Wikipage to another Wikipage	Partial agonist Magnolia grandiflora Cannabinoids GABAA receptor positive allosteric modulators Magnolia virginiana 2-AG Lignans Bark isolate Astrocyte Inverse agonist Rodent model Phenolic compound CB2 receptor COX-2 Neolignan Presenilin 2
sameAs	4-O-Methylhonokiol 4-O-Methylhonokiol 4-O-Methylhonokiol 4-O-Methylhonokiol 4-O-Methylhonokiol
dbp:wikiPageUsesTemplate	dbt:Lignans dbt:Cannabinoidergics dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:GABAAR_PAMs dbt:Reflist dbt:Fdacite
thumbnail	wiki-commons:Special:FilePath/Methylhonokiol.svg?width=300
ImageFile	Methylhonokiol.svg (en)
OtherNames	35 (xsd:integer)
PIN	4 (xsd:integer)
has abstract	4-O-Methylhonokiol is a neolignan, a type of phenolic compound. It is found in the bark of Magnolia grandiflora and in M. virginiana flowers. 4-O-Methylhonokiol is a CB2 receptor ligand (Ki = 50 nM), showing inverse agonism and partial agonism via different pathways (cAMP and Ca2+), which potently inhibits osteoclastogenesis. 4-O-Methylhonokiol further attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway. The different neuroprotective effects reported in rodent models may be mediated via CB2 receptors. 4-O-Methylhonokiol activates CB2 receptors and also inhibits the oxygenation of the major endocannabinoid 2-AG via COX-2 in a substrate-selective manner, thus leading to potential synergistic effects at CB receptors. The same study also provided data that 4-O-methylhonokiol can readily pass the blood–brain barrier. (en)
gold:hypernym	Neolignan
prov:wasDerivedFrom	wikipedia-en:4-O-Methylhonokiol?oldid=1106656022&ns=0
page length (characters) of wiki page	5015 (xsd:nonNegativeInteger)
alternative name	3,5′-Diallyl-2′-hydroxy-4-methoxybiphenyl (en)
IUPAC name	4′-Methoxy-3′,5-di(prop-2-en-1-yl)[1,1′-biphenyl]-2-ol (en)
foaf:isPrimaryTopicOf	wikipedia-en:4-O-Methylhonokiol
is Link from a Wikipage to another Wikipage of	4-O-methylhonokiol Honokiol Magnolia grandiflora C19H20O2 Methylhonokiol 68592-15-4 2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol 3,5′-Diallyl-2′-hydroxy-4-methoxybiphenyl 3,5′-diallyl-2′-hydroxy-4-methoxybiphenyl
is Wikipage redirect of	4-O-methylhonokiol C19H20O2 Methylhonokiol 68592-15-4 2-(4-methoxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol 3,5′-Diallyl-2′-hydroxy-4-methoxybiphenyl 3,5′-diallyl-2′-hydroxy-4-methoxybiphenyl
is foaf:primaryTopic of	wikipedia-en:4-O-Methylhonokiol

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