About: ABCA12

Facets (new session)
Description
Metadata
Settings
- Rule:
- Inverse Functional Properties:
- "Same As":

About: ABCA12 Goto Sponge NotDistinct Permalink

An Entity of Type : umbel-rc:ProteinMolecule, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon

http://dbpedia.demo.openlinksw.com/c/AQv7q7chfS

ATP-binding cassette sub-family A member 12 also known as ATP-binding cassette transporter 12 is a protein that in humans is encoded by the ABCA12 gene. ABCA12 belongs to a group of genes called the ATP-binding cassette family, which makes proteins that transport molecules across cell membranes. The ABCA12 gene is active in some types of skin cells and in several other tissues, such as testis, placenta, lung, stomach, and fetal brain and liver. This protein appears to be essential for normal development of the skin, which provides a barrier between the body and its surrounding environment. It transports , a glucosylceramide, out of the keratinocytes of the stratum corneum of the epidermis.

Attributes	Values
rdf:type	Thing Biomolecule gene Biomolecule Gene yago:WikicatNucleicAcids yago:Abstraction100002137 yago:Arrangement107938773 yago:Chemical114806838 yago:Compound114818238 yago:Gene105436752 yago:Group100031264 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:NucleicAcid114964129 yago:Ordering108456993 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 yago:WikicatHumanGenes HumanGene protein yago:Sequence108459252 yago:Series108457976 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 umbel-rc:ProteinMolecule
rdfs:label	ABCA12 (en) ABCA12 (nl) ABCA12 (uk)
rdfs:comment	ATP-binding cassette sub-family A member 12 also known as ATP-binding cassette transporter 12 is a protein that in humans is encoded by the ABCA12 gene. ABCA12 belongs to a group of genes called the ATP-binding cassette family, which makes proteins that transport molecules across cell membranes. The ABCA12 gene is active in some types of skin cells and in several other tissues, such as testis, placenta, lung, stomach, and fetal brain and liver. This protein appears to be essential for normal development of the skin, which provides a barrier between the body and its surrounding environment. It transports , a glucosylceramide, out of the keratinocytes of the stratum corneum of the epidermis. (en) ATP-binding cassette sub-familie A onderdeel 12, ook wel bekend als ATP-binding cassette transporter 12, is een eiwit dat in het menselijke lichaam onder de gen code ABCA12 geregistreerd staat. Het gen behoort tot een superfamilie genen genaamd ATP-binding-cassette-familie, die verantwoordelijk zijn voor het transport van moleculen naar de diverse celmembranen. ABCA12 is vooral actief in de diverse huidcellen, alsook in andere weefsels en organen zoals bijvoorbeeld de teelbal, placenta, longen, maag, en de lever. Het is overigens ook vrij actief in de hersenen van de foetus. Het gen is verantwoordelijk voor de normale ontwikkeling van de opperhuid, die dient als een beschermende barrière tussen het lichaam en de buitenwereld. Hoewel de precieze functie van ABCA12 nog niet geheel duidelijk (nl) ABCA12 (англ. ATP binding cassette subfamily A member 12) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 595 амінокислот, а молекулярна маса — 293 237. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk)
dct:subject	ATP-binding cassette transporters
Wikipage page ID	3473058 (xsd:integer)
Wikipage revision ID	1077022221 (xsd:integer)
Link from a Wikipage to another Wikipage	Mutation Epidermis (skin) Gene Proceedings of the National Academy of Sciences of the United States of America Lamellar ichthyosis Stratum corneum Adenosine triphosphate Amino acid Base pair Cell membrane Stomach Protein ATP-binding cassette family Harlequin-type ichthyosis ATP-binding cassette transporters Chromosome 2 (human) Lung Skin Placenta Testis Skin cell Glucosylceramide dbr:Epidermoside
Link from a Wikipage to an external page	https://web.archive.org/web/20160305185933/http:/www.genecards.org/cgi-bin/carddisp%3FABCA12
sameAs	ABCA12 ABCA12 ABCA12 ABCA12 ABCA12 ABCA12 ABCA12
dbp:wikiPageUsesTemplate	dbt:UCSC_genome_browser dbt:Cite_journal dbt:Infobox_gene dbt:MeshName dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:ABC_transporters dbt:UCSC_gene_details
has abstract	ATP-binding cassette sub-family A member 12 also known as ATP-binding cassette transporter 12 is a protein that in humans is encoded by the ABCA12 gene. ABCA12 belongs to a group of genes called the ATP-binding cassette family, which makes proteins that transport molecules across cell membranes. The ABCA12 gene is active in some types of skin cells and in several other tissues, such as testis, placenta, lung, stomach, and fetal brain and liver. This protein appears to be essential for normal development of the skin, which provides a barrier between the body and its surrounding environment. It transports , a glucosylceramide, out of the keratinocytes of the stratum corneum of the epidermis. The ABCA12 gene is located on the long (q) arm of chromosome 2 between positions 34 and 35, from base pair 215,621,772 to base pair 215,828,656. (en) ATP-binding cassette sub-familie A onderdeel 12, ook wel bekend als ATP-binding cassette transporter 12, is een eiwit dat in het menselijke lichaam onder de gen code ABCA12 geregistreerd staat. Het gen behoort tot een superfamilie genen genaamd ATP-binding-cassette-familie, die verantwoordelijk zijn voor het transport van moleculen naar de diverse celmembranen. ABCA12 is vooral actief in de diverse huidcellen, alsook in andere weefsels en organen zoals bijvoorbeeld de teelbal, placenta, longen, maag, en de lever. Het is overigens ook vrij actief in de hersenen van de foetus. Het gen is verantwoordelijk voor de normale ontwikkeling van de opperhuid, die dient als een beschermende barrière tussen het lichaam en de buitenwereld. Hoewel de precieze functie van ABCA12 nog niet geheel duidelijk is, suggereren onderzoekers dat het een belangrijke rol speelt bij het transport van lipiden (vet) van en naar de huidcellen, dat gebruikt wordt voor de vorming van de opperhuid (epidermis). Het ABCA12-gen bevindt zich in chromosoom 2 tussen positie 34 en 35 tussen de DNA-basenparen 215,621,772 en 215,828,656. (nl) ABCA12 (англ. ATP binding cassette subfamily A member 12) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 595 амінокислот, а молекулярна маса — 293 237. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у таких біологічних процесах як транспорт, поліморфізм, альтернативний сплайсинг. Білок має сайт для зв'язування з АТФ, нуклеотидами. Локалізований у мембрані. (uk)
gold:hypernym	Protein
prov:wasDerivedFrom	wikipedia-en:ABCA12?oldid=1077022221&ns=0
page length (characters) of wiki page	11561 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:ABCA12
is Link from a Wikipage to another Wikipage of	List of genes mutated in cutaneous conditions List of genetic disorders List of human protein-coding genes 1 Ichthyosis Lamellar ichthyosis ATP-binding cassette transporter ATP-binding domain of ABC transporters Chromosome 2 List of OMIM disorder codes ABCA12 (gene) Harlequin-type ichthyosis Keratosis pilaris

Faceted Search & Find service v1.17_git147 as of Sep 06 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 08.03.3331 as of Sep 2 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 55 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software