About: Acid-sensing ion channel

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Acid-sensing ion channels (ASICs) are neuronal voltage-insensitive sodium channels activated by extracellular protons permeable to Na+. ASIC1 also shows low Ca2+ permeability. ASIC proteins are a subfamily of the ENaC/Deg superfamily of ion channels. These genes have splice variants that encode for several isoforms that are marked by a suffix. In mammals, acid-sensing ion channels (ASIC) are encoded by five genes that produce ASIC protein subunits: ASIC1, ASIC2, ASIC3, ASIC4, and ASIC5. Three of these protein subunits assemble to form the ASIC, which can combine into both homotrimeric and heterotrimeric channels typically found in both the central nervous system and peripheral nervous system. However, the most common ASICs are ASIC1a and ASIC1a/2a and ASIC3. ASIC2b is non-functional on its

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rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Act100030358 yago:Channel106259898 yago:Chemical114806838 yago:Communication106252138 yago:Compound114818238 yago:Event100029378 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:PsychologicalFeature100023100 yago:Relation100031921 yago:WikicatIntegralMembraneProteins yago:WikicatIonChannels yago:YagoPermanentlyLocatedEntity protein television station yago:Substance100019613 yago:Thing100002452 yago:Transmission106251781 yago:Unit109465459
rdfs:label	Acid-sensing ion channel (en) Récepteurs ASIC (fr) 酸感受性イオンチャネル (ja) Кислото-чувствительные ионные каналы (ru)
rdfs:comment	Le rôle fonctionnel des récepteurs ASIC (Acid-sensing ion channel) dans le système nerveux périphérique est lié à la nociception, la perception du goût amer et la modulation de la transmission synaptique. (fr) 酸感受性イオンチャネル（さんかんじゅせいイオンチャネル、英: acid-sensing ion channel、略称: ASIC）は、神経に存在する電位非依存性ナトリウムチャネルである。ASICは細胞外のプロトンによって活性化され、Na+を透過させる。は低いCa2+透過性も示す。ASICタンパク質は、イオンチャネルのENaC/Degスーパーファミリーのサブファミリーを構成する。ASICは哺乳類では5つの遺伝子によってコードされており、ASIC1、、、、のサブユニットが産生される。さらに、選択的スプライシングによるアイソフォームが存在し、末尾のアルファベットで区別される。ASICはこれらのタンパク質サブユニットのうちの3つから組み立てられてられ、中枢神経系と末梢神経系の双方でホモ三量体またはヘテロ三量体として存在する。最も一般的なASICはASIC1a、ASIC1a/2a、ASIC3である。ASIC2bは自身では機能を持たないが、ヘテロ三量体に加わることでチャネル活性を調節する。ASIC4の機能は不明である。ASICは網膜の損傷、発作、虚血性脳損傷などの病態に関与しており、創薬の標的としても期待されている。 (ja) Acid-sensing ion channels (ASICs) are neuronal voltage-insensitive sodium channels activated by extracellular protons permeable to Na+. ASIC1 also shows low Ca2+ permeability. ASIC proteins are a subfamily of the ENaC/Deg superfamily of ion channels. These genes have splice variants that encode for several isoforms that are marked by a suffix. In mammals, acid-sensing ion channels (ASIC) are encoded by five genes that produce ASIC protein subunits: ASIC1, ASIC2, ASIC3, ASIC4, and ASIC5. Three of these protein subunits assemble to form the ASIC, which can combine into both homotrimeric and heterotrimeric channels typically found in both the central nervous system and peripheral nervous system. However, the most common ASICs are ASIC1a and ASIC1a/2a and ASIC3. ASIC2b is non-functional on its (en) Кислото-чувствительные ионные каналы (КЧИК) (англ. Acid-Sensing Ion Channels) — нейронные потенциал-независимые катионные каналы, активируемые внеклеточными протонами. Белки КЧИК являются подсемейством суперсемейства ЭНК ионных каналов. На сегодня распознано пять белков семейства КЧИК, которые кодируются генами ASIC1, ASIC2, ASIC3 и ASIC4. КЧИК1a, 1 и 2a, 2b являются . Кристаллическая структура куриного КЧИК1a была исследована в 2007 году. (ru)
name	Acid-sensing sodium channel (en)
foaf:depiction
dcterms:subject	Articles containing video clips Electrophysiology Integral membrane proteins Ion channels Sodium channels
Wikipage page ID	25327696 (xsd:integer)
Wikipage revision ID	1082974737 (xsd:integer)
Link from a Wikipage to another Wikipage	Protein kinase A Black mamba Depolarization Ligand-gated ion channel Psalmopoeus cambridgei Articles containing video clips Electrophysiology Competitive inhibition Amygdala Voltage-dependent calcium channel Gene Glycerol Pharmacological Apoptosis Peripheral nervous system Protein kinase C Protein kinase Integral membrane proteins Actinin Action potential Lipid bilayer dbr:Amiloride Ion channels Nociceptors Nonsteroidal anti-inflammatory drug PH Central nervous system Glycosylation Organ of Corti Posterior horn of spinal cord Ion channels Ischemia ASIC5 Sodium channels Acidosis Afferent nerve fiber Disulfide bonds Migraine Voltage-gated ion channel Oxidation Mambalgins N-terminus NMDA receptor Phosphorylation Spiral ganglion Drug target Amino acid residues Aspartate N-glycosylation N-linked-Glycan ENaC Isoforms Splice variant

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