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Acotiamide (brand name Acofide, codenamed YM-443 and Z-338) is a drug manufactured and approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. It acts as an acetylcholinesterase inhibitor. It is pending approval in the United States; ten clinical trials have been successfully completed.

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rdf:type
rdfs:label
  • Acotiamide (en)
  • Acotiamida (es)
  • アコチアミド (ja)
rdfs:comment
  • Acotiamide (brand name Acofide, codenamed YM-443 and Z-338) is a drug manufactured and approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. It acts as an acetylcholinesterase inhibitor. It is pending approval in the United States; ten clinical trials have been successfully completed. (en)
  • Acotiamida (YM-443, Z-338) es un experimental inhibidor de la colinesterasa​ (es)
  • アコチアミド(Acotiamide)はコリンエステラーゼ阻害剤の一種。世界初の機能性ディスペプシア (Dyspepsia) 治療薬として使用される。 ゼリア新薬工業により創製された新規化合物で、ゼリア新薬とアステラス製薬が共同開発を行った。開発コードはゼリア新薬がZ338、アステラス製薬がYM443であった。2013年3月25日付で厚生労働省より承認を得て、アコチアミド塩酸塩水和物がアコファイドの商品名で、100mgの錠剤として販売開始された。 (ja)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Acotiamide.svg
dcterms:subject
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dbp:wikiPageUsesTemplate
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ATC prefix
  • None (en)
c
CAS number
ChEMBL
ChemSpiderID
elimination half-life
excretion
  • Feces , urine (en)
H
IUPAC name
  • N-{2-[bisamino]ethyl}-2-{[carbonyl]amino}-1,3-thiazole-4-carboxamide (en)
KEGG
  • D08838 (en)
legal status
  • Rx-only (en)
metabolism
  • UGT1A8 and 1A9 (en)
molecular weight
n
O
PubChem
routes of administration
  • By mouth (en)
s
SMILES
  • O=Cc2ccccc2O (en)
StdInChI
StdInChIKey
  • TWHZNAUBXFZMCA-UHFFFAOYSA-N (en)
tradename
  • Acofide (en)
UNII
  • D42OWK5383 (en)
Verifiedfields
  • changed (en)
verifiedrevid
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