State Route 216 (SR 216) is a numbered state highway in Tuscaloosa County, Alabama. SR 216 follows the former route of US 11 through eastern Tuscaloosa County. It serves as an alternate route between Bessemer and Tuscaloosa (the other routes being I-20/59 and US 11). The route was commissioned in April 1978 after ALDOT took over the route formerly maintained by Tuscaloosa County as County Road 116.