About: Alireza Mashaghi

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Alireza Mashaghi is a biophysicist and medical scientist at Leiden University. He is known for his contributions to single-molecule analysis of chaperone assisted protein folding, molecular topology and medical systems biophysics. In 2018, Mashaghi has been named as "Discoverer of the Year" by Leiden University. He is the recipient of several awards including an honorarium from American Chemical Society.

Attributes	Values
rdf:type	Thing foaf:Person person dul:NaturalPerson Eukaryote Person Human Animal animal eukaryote scientist species schema:Person Scientist
rdfs:label	Alireza Mashaghi (en)
rdfs:comment	Alireza Mashaghi is a biophysicist and medical scientist at Leiden University. He is known for his contributions to single-molecule analysis of chaperone assisted protein folding, molecular topology and medical systems biophysics. In 2018, Mashaghi has been named as "Discoverer of the Year" by Leiden University. He is the recipient of several awards including an honorarium from American Chemical Society. (en)
foaf:name	Alireza Mashaghi (en)
name	Alireza Mashaghi (en)
dcterms:subject	Dutch ophthalmologists Living people Year of birth missing (living people) ETH Zurich alumni Harvard University staff Leiden University faculty Biophysicists
Wikipage page ID	56039674 (xsd:integer)
Wikipage revision ID	1081575616 (xsd:integer)
Link from a Wikipage to another Wikipage	Delft University of Technology Dutch ophthalmologists University of Tehran Topology (chemistry) Living people Year of birth missing (living people) Massachusetts Institute of Technology Nature (journal) Organ-on-a-chip Cornea Anthony A. Hyman Leiden University Stem cell Physics Omics ETH Zurich alumni Harvard University staff Leiden University faculty Cees Dekker Lipid bilayer Reza Dana American Chemical Society ETH Zurich Protein folding Harvard University AMOLF Biophysicists Colin Adams (mathematician) Ebola Donald E. Ingber Circuit topology Huib Bakker Max Planck Institutes Ophthalmology Chaperone (protein) Medicine Nano Research Scientific Reports Medical diagnostics Statistical physics Single-molecule experiment Petra Schwille Virology DnaK Hemorrhagic fever
sameAs	Alireza Mashaghi Alireza Mashaghi Alireza Mashaghi
work institution	Leiden University Harvard University
dbp:wikiPageUsesTemplate	dbt:Authority_control dbt:Reflist dbt:Infobox_scientist
alma mater	Delft University of Technology University of Tehran ETH Zurich Harvard University
awards	Discoverer of the Year 2018, Muscular Dystrophy Association Award 2019 (en)
field	Physics Medicine
known for	Organ-on-a-chip Circuit topology Medical diagnostics Single-molecule experiment
has abstract	Alireza Mashaghi is a biophysicist and medical scientist at Leiden University. He is known for his contributions to single-molecule analysis of chaperone assisted protein folding, molecular topology and medical systems biophysics. Mashaghi made the first observation of direct chaperone involvement during folding of a protein. This work which has been published in Nature solved a long-standing puzzle in biology. In 2017, he reported a new model for chaperone DnaK function and made a discovery that, according to Ans Hekkenberg, "overturns the decades-old textbook model of action for a protein that is central for many processes in living cells". He and his co-workers found that chaperone DnaK can recognise natively folded protein parts and stabilise them. Inspired by single-molecule analysis of biopolymers, Mashaghi and his team developed a new topology framework, termed as circuit topology for studying folding of linear chains. Mashaghi also contributed to others areas in biophysics and biotechnology including membrane biophysics and membrane sensing, nanoparticle technology, and organ-on-a-chip technology. In particular, the Mashaghi team was one of the first to introduce Organ Chip technology to the field of virology. For example, his team engineered the first chip-based disease model for Ebola hemorrhagic shock syndrome. Mashaghi is also active in interdisciplinary research in ophthalmology and clinical medicine. In 2017, he and his co-workers at Harvard developed an immunotherapy strategy to improve survival of cornea grafts. The work which gained significant media attention, provides hope for patients with inflamed cornea bed, typically suffering from high graft rejection rates. Together with his co-workers, he contributed to the use of stem cell technology, omics technology, and systems biophysics approaches in ophthalmology. Furthermore, in their research, Alireza Mashaghi and his team are linking statistical physics and medical diagnostics; this unprecedented link between physics and medicine may allow for early and efficient diagnosis of certain diseases. During his academic career, Mashaghi has been affiliated with various institutions including Harvard University, Leiden University, Massachusetts Institute of Technology, Delft University of Technology, ETH Zurich, Max Planck Institutes, and AMOLF. Mashaghi has published more that 100 papers in peer-reviewed scientific journals including several papers in Nature and Nature specialty journals. He worked and co-authored with Cees Dekker, Anthony A. Hyman, Colin Adams, Donald E. Ingber, Huib Bakker, Reza Dana, and Petra Schwille. He serves on editorial board of several journals including Nano Research and Scientific Reports. In 2018, Mashaghi has been named as "Discoverer of the Year" by Leiden University. He is the recipient of several awards including an honorarium from American Chemical Society. (en)
prov:wasDerivedFrom	wikipedia-en:Alireza_Mashaghi?oldid=1081575616&ns=0
page length (characters) of wiki page	6681 (xsd:nonNegativeInteger)
academic discipline	Physics Medicine
alma mater	Delft University of Technology University of Tehran ETH Zurich Harvard University

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