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Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family, which specifically target histone protein subunits or histone complexes. They were first reported by Henry Kunkel, H.R. Holman, and H.R.G. Dreicher in their studies of cellular causes of lupus erythematosus in 1959–60. Today, anti-histone antibodies are still used as a marker for systemic lupus erythematosus, but are also implicated in other autoimmune diseases like Sjögren syndrome, dermatomyositis, or rheumatoid arthritis. Anti-histone antibodies can be used as a marker for drug-induced lupus.

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  • Anti-histone antibodies (en)
  • Anticorpi anti-istone (it)
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  • Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family, which specifically target histone protein subunits or histone complexes. They were first reported by Henry Kunkel, H.R. Holman, and H.R.G. Dreicher in their studies of cellular causes of lupus erythematosus in 1959–60. Today, anti-histone antibodies are still used as a marker for systemic lupus erythematosus, but are also implicated in other autoimmune diseases like Sjögren syndrome, dermatomyositis, or rheumatoid arthritis. Anti-histone antibodies can be used as a marker for drug-induced lupus. (en)
  • Gli anticorpi anti-istone sono autoanticorpi che risultano presenti nel 50-70% dei pazienti con lupus eritematoso sistemico (LES) e in più del 95% dei pazienti con lupus eritematoso indotto da farmaci. In altre parole il dosaggio di questi anticorpi permette una sensibilità rispettivamente del 50-70% e del 95% nella diagnosi di tali malattie. Tali anticorpi legano gli istoni, delle proteine basiche associate ai cromosomi nella formazione del nucleosoma. Gli anticorpi contro gli istoni H3 e H4 sembrano essere quelli maggiormente coinvolti nella genesi delle malattie reumatiche. (it)
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  • Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family, which specifically target histone protein subunits or histone complexes. They were first reported by Henry Kunkel, H.R. Holman, and H.R.G. Dreicher in their studies of cellular causes of lupus erythematosus in 1959–60. Today, anti-histone antibodies are still used as a marker for systemic lupus erythematosus, but are also implicated in other autoimmune diseases like Sjögren syndrome, dermatomyositis, or rheumatoid arthritis. Anti-histone antibodies can be used as a marker for drug-induced lupus. (en)
  • Gli anticorpi anti-istone sono autoanticorpi che risultano presenti nel 50-70% dei pazienti con lupus eritematoso sistemico (LES) e in più del 95% dei pazienti con lupus eritematoso indotto da farmaci. In altre parole il dosaggio di questi anticorpi permette una sensibilità rispettivamente del 50-70% e del 95% nella diagnosi di tali malattie. Tali anticorpi legano gli istoni, delle proteine basiche associate ai cromosomi nella formazione del nucleosoma. Gli anticorpi contro gli istoni H3 e H4 sembrano essere quelli maggiormente coinvolti nella genesi delle malattie reumatiche. Altre malattie in cui questi anticorpi risultano presenti sono l'artrite reumatoide, l'AIDS, le vasculiti e la cirrosi biliare primitiva. Il test immunoenzimatico ELISA che viene utilizzato per valutare la presenza di tali anticorpi risulta positivo quando sono presenti più di 25 anticorpi anti-istone per ml di sangue. (it)
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