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About: Aurora inhibitor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatProteinKinaseInhibitors, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: yago:Inhibitor114724436yago:Matter100020827yago:PhysicalEntity100001930yago:Substance100020090yago:WikicatProteinKinaseInhibitors New Facet based on Instances of this Class

Aurora kinase inhibitors are a putative drug class for treating cancer. The Aurora kinase enzymes could be potential targets for novel small-molecule enzyme inhibitors. Aurora kinases regulate cell cycle transit from G2 through cytokinesis, and thus are targets in cancer therapy. There are three mammalian aurora kinase genes, encoding aurora A, B and C. Intense investigation has focused on aurora A and B as they appear to play a role in oncogenesis with aurora A identified as a low penetrance tumor susceptibility gene in mice and humans.