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Azidomorphine is an opiate analogue that is a derivative of morphine, where the 7,8 double bond has been saturated and the 6-hydroxy group has been replaced by an azide group. Azidomorphine binds with high affinity to the mu opioid receptor, and is around 40x more potent than morphine in vivo. It has similar effects to morphine, including analgesia, sedation, and respiratory depression. However, its addiction liability has been found to be slightly lower than that of morphine in animal studies.

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  • Azidomorphine (en)
  • アジドモルヒネ (ja)
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  • Azidomorphine is an opiate analogue that is a derivative of morphine, where the 7,8 double bond has been saturated and the 6-hydroxy group has been replaced by an azide group. Azidomorphine binds with high affinity to the mu opioid receptor, and is around 40x more potent than morphine in vivo. It has similar effects to morphine, including analgesia, sedation, and respiratory depression. However, its addiction liability has been found to be slightly lower than that of morphine in animal studies. (en)
  • アジドモルヒネ(Azidomorphine)は、モルヒネの7,8二重結合が飽和し、6-ヒドロキシ基がアジド基に置換したオピエートのアナログである。 アジドモルヒネは、に高いアフィニティで結合し、in vivoでモルヒネの約40倍の強さを持つ。モルヒネと同様の鎮痛剤、鎮静剤、呼吸抑制等の作用を持つが、動物実験では、依存性はモルヒネより若干低いことが示されている。 (ja)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Azidomorphine-3D-spacefill.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Azidomorphine2DCSD2.svg
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  • Skeletal formula of azidomorphine (en)
  • Space-filling model of the azidomorphine molecule (en)
ATC prefix
  • none (en)
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CAS number
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image
  • Azidomorphine-3D-spacefill.png (en)
IUPAC name
  • -Azido-4,5-α-epoxy-17-methyl morphinan-3-ol (en)
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PubChem
SMILES
  • [N-]=[N+]=N\[C@H]4[C@@H]5Oc1c2cC[C@H]3NC (en)
StdInChI
StdInChIKey
  • KZOKOEQTKWBKOK-XHQKLZHNSA-N (en)
synonyms
  • Azidomorphine (en)
UNII
  • U973VU74ER (en)
Verifiedfields
  • changed (en)
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  • changed (en)
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  • Azidomorphine is an opiate analogue that is a derivative of morphine, where the 7,8 double bond has been saturated and the 6-hydroxy group has been replaced by an azide group. Azidomorphine binds with high affinity to the mu opioid receptor, and is around 40x more potent than morphine in vivo. It has similar effects to morphine, including analgesia, sedation, and respiratory depression. However, its addiction liability has been found to be slightly lower than that of morphine in animal studies. (en)
  • アジドモルヒネ(Azidomorphine)は、モルヒネの7,8二重結合が飽和し、6-ヒドロキシ基がアジド基に置換したオピエートのアナログである。 アジドモルヒネは、に高いアフィニティで結合し、in vivoでモルヒネの約40倍の強さを持つ。モルヒネと同様の鎮痛剤、鎮静剤、呼吸抑制等の作用を持つが、動物実験では、依存性はモルヒネより若干低いことが示されている。 (ja)
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