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BCM theory, BCM synaptic modification, or the BCM rule, named for , Leon Cooper, and Paul Munro, is a physical theory of learning in the visual cortex developed in 1981. The BCM model proposes a sliding threshold for long-term potentiation (LTP) or long-term depression (LTD) induction, and states that synaptic plasticity is stabilized by a dynamic adaptation of the time-averaged postsynaptic activity. According to the BCM model, when a pre-synaptic neuron fires, the post-synaptic neurons will tend to undergo LTP if it is in a high-activity state (e.g., is firing at high frequency, and/or has high internal calcium concentrations), or LTD if it is in a lower-activity state (e.g., firing in low frequency, low internal calcium concentrations). This theory is often used to explain how cortical

Attributes	Values
rdf:type	work
rdfs:label	BCM theory (en) Règle BCM (fr)
rdfs:comment	BCM theory, BCM synaptic modification, or the BCM rule, named for , Leon Cooper, and Paul Munro, is a physical theory of learning in the visual cortex developed in 1981. The BCM model proposes a sliding threshold for long-term potentiation (LTP) or long-term depression (LTD) induction, and states that synaptic plasticity is stabilized by a dynamic adaptation of the time-averaged postsynaptic activity. According to the BCM model, when a pre-synaptic neuron fires, the post-synaptic neurons will tend to undergo LTP if it is in a high-activity state (e.g., is firing at high frequency, and/or has high internal calcium concentrations), or LTD if it is in a lower-activity state (e.g., firing in low frequency, low internal calcium concentrations). This theory is often used to explain how cortical (en) La théorie BCM, la modification synaptique BCM, ou la règle BCM, du nom d'Elie Bienenstock, Leon Cooper et Paul Munro, est une théorie décrivant les changements d'adaptation neuronale dans le cerveau ou dans un réseau de neurones pendant un processus d'apprentissage. Elle a initialement postulé pour l'apprentissage dans le cortex visuel en 1981. Le modèle BCM propose un seuil mobile pour l'induction de la potentialisation à long terme (LTP) ou de la dépression à long terme (LTD), et indique que la plasticité synaptique est stabilisée par une adaptation dynamique de l'activité post-synaptique moyennée dans le temps. (fr)
dcterms:subject	Biophysics Computational neuroscience Neuroplasticity
Wikipage page ID	14200011 (xsd:integer)
Wikipage revision ID	1073259256 (xsd:integer)
Link from a Wikipage to another Wikipage	Purkinje cell Monocular deprivation Normalisable wave function Biophysics Leon Cooper Synaptic plasticity Computational neuroscience Neuroplasticity Cerebellum Long-term depression Long-term potentiation Hippocampus Visual cortex Donald Hebb Serena Dudek Parallel fiber Parallel distributed processing Hebbian learning dbr:Elie_Bienenstock
Link from a Wikipage to an external page	http://www.scholarpedia.org/article/BCM_rule
sameAs	BCM theory BCM theory BCM theory BCM theory
dbp:wikiPageUsesTemplate	dbt:Confusing dbt:Reflist dbt:Short_description
has abstract	BCM theory, BCM synaptic modification, or the BCM rule, named for , Leon Cooper, and Paul Munro, is a physical theory of learning in the visual cortex developed in 1981. The BCM model proposes a sliding threshold for long-term potentiation (LTP) or long-term depression (LTD) induction, and states that synaptic plasticity is stabilized by a dynamic adaptation of the time-averaged postsynaptic activity. According to the BCM model, when a pre-synaptic neuron fires, the post-synaptic neurons will tend to undergo LTP if it is in a high-activity state (e.g., is firing at high frequency, and/or has high internal calcium concentrations), or LTD if it is in a lower-activity state (e.g., firing in low frequency, low internal calcium concentrations). This theory is often used to explain how cortical neurons can undergo both LTP or LTD depending on different conditioning stimulus protocols applied to pre-synaptic neurons (usually high-frequency stimulation, or HFS, for LTP, or low-frequency stimulation, LFS, for LTD). (en) La théorie BCM, la modification synaptique BCM, ou la règle BCM, du nom d'Elie Bienenstock, Leon Cooper et Paul Munro, est une théorie décrivant les changements d'adaptation neuronale dans le cerveau ou dans un réseau de neurones pendant un processus d'apprentissage. Elle a initialement postulé pour l'apprentissage dans le cortex visuel en 1981. Le modèle BCM propose un seuil mobile pour l'induction de la potentialisation à long terme (LTP) ou de la dépression à long terme (LTD), et indique que la plasticité synaptique est stabilisée par une adaptation dynamique de l'activité post-synaptique moyennée dans le temps. Selon le modèle BCM, lorsqu'un neurone pré-synaptique se déclenche, les neurones post-synaptiques auront tendance à subir une LTP s'il est dans un état de haute activité (par exemple, se déclenche à haute fréquence et/ou a des concentrations internes élevées en calcium ), ou LTD s'il est dans un état d'activité plus faible (par exemple, déclenchement à basse fréquence, faibles concentrations internes de calcium). Cette théorie est souvent utilisée pour expliquer comment les neurones corticaux peuvent subir à la fois LTP ou LTD en fonction de différents protocoles de stimulation de conditionnement appliqués aux neurones pré-synaptiques (généralement stimulation haute fréquence, ou HFS, pour LTP, ou stimulation basse fréquence, LFS, pour LTD). (fr)
gold:hypernym	Theory
prov:wasDerivedFrom	wikipedia-en:BCM_theory?oldid=1073259256&ns=0
page length (characters) of wiki page	15135 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:BCM_theory
is Link from a Wikipage to another Wikipage of	BCM BCM Theory Neural network Leon Cooper Hebbian theory Learning rule List of Brown University faculty Long-term depression Oja's rule Synaptic weight Serena Dudek
is Wikipage redirect of	BCM Theory
is Wikipage disambiguates of	BCM
is known for of	Leon Cooper
is known for of	Leon Cooper
is foaf:primaryTopic of	wikipedia-en:BCM_theory

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