About: Bacterial Leucine Transporter

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Bacterial Leucine Transporter (LeuT) is a bundled twelve alpha helix protein which belongs to the family of transporters that shuttle amino acids in and out of bacterial cells. Specialized in small hydrophobic amino acids such as leucine and alanine, this transporter is powered by the gradient of sodium ions that is normally maintained by healthy cells across their membranes. LeuT acts as a symporter, which means that it links the passage of a sodium ion across the cell membrane with the transport of the amino acid in the same direction. It was first crystallized to understand the inner molecular mechanisms of antidepressant's work since it has a close resemblance with the human neurotransmitter transporters (more difficult to crystallize) that these drugs block, thus inhibiting the reupta

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein protein
rdfs:label	Bacterial Leucine Transporter (en)
rdfs:comment	Bacterial Leucine Transporter (LeuT) is a bundled twelve alpha helix protein which belongs to the family of transporters that shuttle amino acids in and out of bacterial cells. Specialized in small hydrophobic amino acids such as leucine and alanine, this transporter is powered by the gradient of sodium ions that is normally maintained by healthy cells across their membranes. LeuT acts as a symporter, which means that it links the passage of a sodium ion across the cell membrane with the transport of the amino acid in the same direction. It was first crystallized to understand the inner molecular mechanisms of antidepressant's work since it has a close resemblance with the human neurotransmitter transporters (more difficult to crystallize) that these drugs block, thus inhibiting the reupta (en)
name	Bacterial Leucine Transporter (en)
foaf:depiction
dcterms:subject	Articles containing video clips Transport proteins
Wikipage page ID	44180583 (xsd:integer)
Wikipage revision ID	1110545660 (xsd:integer)
Link from a Wikipage to another Wikipage	Membrane transport protein Aquifex aeolicus Dopamine transporter Articles containing video clips GABA Glial cells Glycine Conformational change Antidepressant Leucine Protein subunit Axons Bacterial Transport proteins Active transport Tyrosine Docking (molecular) Crystallized Alanine Alpha helix Amino acids Noradrenaline Cell membrane Protein Isoleucine Cotransporter Transmembrane protein Arginine Neurotransmitter transporter dbr:Dopamine Phenylalanine Sodium Hydrophobic dbr:Serotonin Sequence homology Turn (biochemistry) Symporter Pharmacology of antidepressants Selective serotonin reuptake inhibitors Bilayer lipid membrane Beta strand Homodimer Neurotransmitter transporters
sameAs	Bacterial Leucine Transporter Bacterial Leucine Transporter Bacterial Leucine Transporter Bacterial Leucine Transporter
dbp:wikiPageUsesTemplate	dbt:Reflist dbt:Infobox_protein
thumbnail	wiki-commons:Special:FilePath/LeuT_(polar_and_non_polar_residues).png?width=300
caption	Molecular dynamics simulation of LeuT generated using GROMACS (en)
symbol	LeuT (en)
UniProt	O67854 (en)
has abstract	Bacterial Leucine Transporter (LeuT) is a bundled twelve alpha helix protein which belongs to the family of transporters that shuttle amino acids in and out of bacterial cells. Specialized in small hydrophobic amino acids such as leucine and alanine, this transporter is powered by the gradient of sodium ions that is normally maintained by healthy cells across their membranes. LeuT acts as a symporter, which means that it links the passage of a sodium ion across the cell membrane with the transport of the amino acid in the same direction. It was first crystallized to understand the inner molecular mechanisms of antidepressant's work since it has a close resemblance with the human neurotransmitter transporters (more difficult to crystallize) that these drugs block, thus inhibiting the reuptake of chemical messengers across the cell membrane of nerve axons and glial cells. (en)
PDB	3 (xsd:integer)
RefSeq	NP_214423.1. NC_000918.1. (en)
gold:hypernym	Protein
PDB ID	3F3E
RefSeq	NP_214423.1. NC_000918.1.
UniProt	O67854
prov:wasDerivedFrom	wikipedia-en:Bacterial_Leucine_Transporter?oldid=1110545660&ns=0
page length (characters) of wiki page	10268 (xsd:nonNegativeInteger)
Symbol	LeuT
foaf:isPrimaryTopicOf	wikipedia-en:Bacterial_Leucine_Transporter
is Link from a Wikipage to another Wikipage of	Amino acid transporter Bacterial leucine transporter Natural resistance-associated macrophage protein
is Wikipage redirect of	Bacterial leucine transporter
is foaf:primaryTopic of	wikipedia-en:Bacterial_Leucine_Transporter

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