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About: Barrier-to-autointegration factor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Unit108189659, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: ThingBiomoleculeBiomoleculeProteinyago:Abstraction100002137yago:Family108078020yago:Group100031264yago:Organization108008335yago:YagoLegalActoryago:YagoLegalActorGeoyago:YagoPermanentlyLocatedEntityproteinyago:SocialGroup107950920yago:Unit108189659 New Facet based on Instances of this Class

In molecular biology, barrier-to-autointegration factor (BAF) is a family of essential proteins that is highly conserved in metazoan evolution, and which may act as DNA-bridging proteins. BAF binds directly to double-stranded DNA, to transcription activators, and to inner nuclear membrane proteins, including lamin A filaments that anchor nuclear pore complexes in place, and nuclear LEM-domain proteins that bind to laminin filaments and chromatin. New findings suggest that BAF has structural roles in nuclear assembly and chromatin organization, represses gene expression and might interlink chromatin structure, nuclear architecture and gene regulation in metazoans.