Beauvericin is a depsipeptide with antibiotic and insecticidal effects belonging to the enniatin family. It was isolated from the fungus Beauveria bassiana, but is also produced by several other fungi, including several Fusarium species; it may therefore occur in grain (such as corn, wheat and barley) contaminated with these fungi. Beauvericin is active against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals.
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| - Beauvericin (en)
- Beauvericina (it)
- ビューベリシン (ja)
- Beauwerycyna (pl)
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| - La beauvericina è un con effetti antibiotici ed insetticidi, appartenente alla famiglia delle enniatine. È stata isolata da funghi della famiglia Beauveria bassiana, ma è anche prodotta da diversi altri funghi della specie Fusarium species;Può quindi trovarsi anche in cereali tipo granturco, grano od orzo contaminati da funghi. La beauvericina è attiva contro batteri gram-positivi e , ed è anche capace di indurre morte cellulare programmata nei mammiferi. (it)
- ビューベリシン (beauvericin) はエンニアチン系のデプシペプチドである。この物質は抗生物質かつ殺虫剤である。Beauveria bassianaやフザリウム属などの真菌から単離される。トウモロコシや小麦、大麦などの穀類が上記真菌に汚染された現場でビューベリジンが見出される。グラム陽性菌とマイコバクテリウム属に有効であり、哺乳類動物のプログラム細胞死も引き起こす。 ビューベリシンは、N-メチル-フェニルアラニル残基とD-ヒドロキシ-イソ-バレリル残基を持つ環状ヘキサデプシペプチドである。イオンとの結合能があり、有毒なアルカリ土類金属とアルカリ金属を細胞膜に透過させ細胞内へと輸送する。 ビューベリシンは、抗真菌薬ケトコナゾールと併用した場合、0.1 μg/mLの投与量でCandida parapsilosisに対してin vitroで殺菌効果を有する。この真菌に感染したマウスに投与したところ、真菌の細胞障害性の低下とマウスの生存率の増加が確認された。 (ja)
- Beauwerycyna – organiczny związek chemiczny z grupy makrocyklicznych depsypeptydów, antybiotyk jonoforowy i mykotoksyna, produkowana przez grzyby z rodzaju Fusarium: , i . (pl)
- Beauvericin is a depsipeptide with antibiotic and insecticidal effects belonging to the enniatin family. It was isolated from the fungus Beauveria bassiana, but is also produced by several other fungi, including several Fusarium species; it may therefore occur in grain (such as corn, wheat and barley) contaminated with these fungi. Beauvericin is active against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals. (en)
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| - Beauvericin.svg (en)
- Beauvericin_3d_structure.png (en)
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| - Beauvericin is a depsipeptide with antibiotic and insecticidal effects belonging to the enniatin family. It was isolated from the fungus Beauveria bassiana, but is also produced by several other fungi, including several Fusarium species; it may therefore occur in grain (such as corn, wheat and barley) contaminated with these fungi. Beauvericin is active against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals. Chemically, beauvericin is a cyclic hexadepsipeptide with alternating N-methyl-phenylalanyl and D-hydroxy-iso-valeryl residues. Its ion-complexing capability allows beauvericin to transport alkaline earth metal and alkali metal ions across cell membranes. Beauvericin has in vitro fungicidal effects on Candida parapsilosis when used in combination with the antifungal drug ketoconazole at dosages of 0.1 μg/ml. Increased survivability rates and low cytotoxicity were also observed in mouse models. (en)
- La beauvericina è un con effetti antibiotici ed insetticidi, appartenente alla famiglia delle enniatine. È stata isolata da funghi della famiglia Beauveria bassiana, ma è anche prodotta da diversi altri funghi della specie Fusarium species;Può quindi trovarsi anche in cereali tipo granturco, grano od orzo contaminati da funghi. La beauvericina è attiva contro batteri gram-positivi e , ed è anche capace di indurre morte cellulare programmata nei mammiferi. (it)
- ビューベリシン (beauvericin) はエンニアチン系のデプシペプチドである。この物質は抗生物質かつ殺虫剤である。Beauveria bassianaやフザリウム属などの真菌から単離される。トウモロコシや小麦、大麦などの穀類が上記真菌に汚染された現場でビューベリジンが見出される。グラム陽性菌とマイコバクテリウム属に有効であり、哺乳類動物のプログラム細胞死も引き起こす。 ビューベリシンは、N-メチル-フェニルアラニル残基とD-ヒドロキシ-イソ-バレリル残基を持つ環状ヘキサデプシペプチドである。イオンとの結合能があり、有毒なアルカリ土類金属とアルカリ金属を細胞膜に透過させ細胞内へと輸送する。 ビューベリシンは、抗真菌薬ケトコナゾールと併用した場合、0.1 μg/mLの投与量でCandida parapsilosisに対してin vitroで殺菌効果を有する。この真菌に感染したマウスに投与したところ、真菌の細胞障害性の低下とマウスの生存率の増加が確認された。 (ja)
- Beauwerycyna – organiczny związek chemiczny z grupy makrocyklicznych depsypeptydów, antybiotyk jonoforowy i mykotoksyna, produkowana przez grzyby z rodzaju Fusarium: , i . (pl)
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