About: Bicifadine

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An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
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Bicifadine (DOV-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) discovered at American Cyanamid as an analgesic drug candidate, and licensed to DOV Pharmaceutical in 1998 after American Cyanamid was acquired by Wyeth.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatAnalgesics yago:WikicatCyclopropanes yago:WikicatSerotonin-norepinephrineReuptakeInhibitors yago:Agent114778436 yago:Analgesic102707683 yago:Anesthetic102710766 yago:CausalAgent100007347 yago:Cyclopropane103155661 yago:Drug103247620 yago:GeneralAnesthetic103433434 yago:InhalationAnesthetic103570838 yago:Inhibitor114724436 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 drug yago:Substance100020090 umbel-rc:DrugProduct
rdfs:label	Bicifadine (en)
rdfs:comment	Bicifadine (DOV-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) discovered at American Cyanamid as an analgesic drug candidate, and licensed to DOV Pharmaceutical in 1998 after American Cyanamid was acquired by Wyeth. (en)
foaf:depiction
dcterms:subject	Abandoned drugs Analgesics Cyclopropanes Pyrrolidines 4-Tolyl compounds Serotonin–norepinephrine–dopamine reuptake inhibitors
Wikipage page ID	14724536 (xsd:integer)
Wikipage revision ID	1115640016 (xsd:integer)
Link from a Wikipage to another Wikipage	Noradrenaline transporter DOV Pharmaceutical Dopamine transporter Abandoned drugs Analgesics Cyclopropanes Pyrrolidines NSAID American Cyanamid Analgesic 4-Tolyl compounds DOV-216,303 Diabetic neuropathy Serotonin–norepinephrine–dopamine reuptake inhibitors Opioid Wyeth Mechanism of action dbr:Serotonin_transporter Monoamine transporter Serotonin-norepinephrine-dopamine reuptake inhibitor Triple reuptake inhibitor
sameAs	Bicifadine Bicifadine Bicifadine Bicifadine Bicifadine Bicifadine
dbp:wikiPageUsesTemplate	dbt:Analgesics dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Antidepressants dbt:Monoamine_reuptake_inhibitors
thumbnail	wiki-commons:Special:FilePath/Bicifadine.svg?width=300
ATC prefix	none (en)
c	12 (xsd:integer)
CAS number	71195 (xsd:integer)
ChEMBL	511099 (xsd:integer)
ChemSpiderID	9889978 (xsd:integer)
elimination half-life	5760.0 (second)
excretion	renal (en)
H	15 (xsd:integer)
IUPAC name	1 (xsd:integer)
legal US	Unscheduled (en)
n	1 (xsd:integer)
PubChem	47953 (xsd:integer)
routes of administration	Oral (en)
SMILES	c1cc[C@]32CNC[C@@H]2C3 (en)
StdInChI	1 (xsd:integer)
StdInChIKey	OFYVIGTWSQPCLF-NWDGAFQWSA-N (en)
UNII	B0SV3N7J3H (en)
Verifiedfields	changed (en)
verifiedrevid	462798006 (xsd:integer)
Watchedfields	changed (en)
width	170 (xsd:integer)
has abstract	Bicifadine (DOV-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) discovered at American Cyanamid as an analgesic drug candidate, and licensed to DOV Pharmaceutical in 1998 after American Cyanamid was acquired by Wyeth. In January 2007, Dov licensed the rights to bicifadine to XTL Biopharmaceuticals after bicifadine failed in a Phase III clinical trial for chronic lower back pain. XTL ran a PhaseIIb clinical trial for pain caused by diabetic neuropathy, which failed in 2008; XTL terminated the agreement in 2010. In 2010 Dov was acquired by Euthymics Bioscience which intended to continue development of other candidates from Dov's portfolio. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad-spectrum monoamine transporter inhibitor or "triple reuptake inhibitor." (en)
gold:hypernym	Inhibitor
prov:wasDerivedFrom	wikipedia-en:Bicifadine?oldid=1115640016&ns=0
page length (characters) of wiki page	6328 (xsd:nonNegativeInteger)
CAS number	71195-57-8
ChEMBL	511099
FDA UNII code	B0SV3N7J3H

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