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About: Bifemelane     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatAminesyago:Abstraction100002137yago:AliphaticCompound114601294yago:Amine114739004yago:Chemical114806838yago:Compound114818238yago:Element114840755yago:Material114580897yago:Matter100020827yago:MethaneSeries114951377yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Quintessence114847103yago:Relation100031921drugyago:Substance100019613yago:WikicatPhenolEthersumbel-rc:DrugProduct New Facet based on Instances of this Class

Bifemelane (INN) (Alnert, Celeport), or bifemelane hydrochloride (JAN), also known as 4-(O-benzylphenoxy)-N-methylbutylamine, is an antidepressant and cerebral activator that is widely used in the treatment of cerebral infarction patients with depressive symptoms in Japan, and in the treatment of senile dementia as well. It also appears to be useful in the treatment of glaucoma. Bifemelane acts as a monoamine oxidase inhibitor (MAOI) of both isoenzymes, with competitive (reversible) inhibition of MAO-A (Ki = 4.20 μM) (making it a reversible inhibitor of monoamine oxidase A (RIMA)) and non-competitive (irreversible) inhibition of MAO-B (Ki = 46.0 μM), and also acts (weakly) as a norepinephrine reuptake inhibitor. The drug has nootropic, neuroprotective, and antidepressant-like effects in an