About: Biotin deficiency

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Biotin deficiency is a nutritional disorder which can become serious, even fatal, if allowed to progress untreated. It can occur in people of any age, ancestry, or of either sex. Biotin is part of the B vitamin family. Biotin deficiency rarely occurs among healthy people because the daily requirement of biotin is low, many foods provide adequate amounts of it, intestinal bacteria synthesize small amounts of it, and the body effectively scavenges and recycles it in the kidneys during production of urine. However, deficiencies can be caused by consuming raw egg whites over a period of weeks to months. Egg whites contain high levels of avidin, a protein that binds biotin strongly. When cooked, avidin is partially denatured and binding to biotin is reduced. However one study showed that 30-40%

Attributes	Values
rdf:type	Thing Disease yago:WikicatVitaminDeficiencies yago:Abstraction100002137 yago:Attribute100024264 yago:Condition113920835 yago:Disease114070360 yago:IllHealth114052046 yago:Illness114061805 yago:Lack114449405 yago:Need114449126 yago:PathologicalState114051917 yago:PhysicalCondition114034177 disease yago:State100024720 umbel-rc:AilmentCondition
rdfs:label	Biotin deficiency (en) Deficiência de biotina (pt)
rdfs:comment	Deficiência de biotina é uma condição na qual não há reservas suficientes de biotina no corpo necessárias para as atividades metabólicas normais. (pt) Biotin deficiency is a nutritional disorder which can become serious, even fatal, if allowed to progress untreated. It can occur in people of any age, ancestry, or of either sex. Biotin is part of the B vitamin family. Biotin deficiency rarely occurs among healthy people because the daily requirement of biotin is low, many foods provide adequate amounts of it, intestinal bacteria synthesize small amounts of it, and the body effectively scavenges and recycles it in the kidneys during production of urine. However, deficiencies can be caused by consuming raw egg whites over a period of weeks to months. Egg whites contain high levels of avidin, a protein that binds biotin strongly. When cooked, avidin is partially denatured and binding to biotin is reduced. However one study showed that 30-40% (en)
foaf:name	Biotin deficiency (en)
name	Biotin deficiency (en)
foaf:depiction
dcterms:subject	Vitamin deficiencies
Wikipage page ID	11453812 (xsd:integer)
Wikipage revision ID	1122303243 (xsd:integer)
Link from a Wikipage to another Wikipage	Carbamazepine Primidone Mutation dbr:Biotin Biotinidase deficiency Dermatitis Antibiotic Anticonvulsant Homeostasis Homozygous DNA Vasopressin Depression (mood) Alopecia Lethargy Transposable elements Lymphocytes Short bowel syndrome Denaturation (biochemistry) Fatty acid metabolism Hallucination Bacteria Total parenteral nutrition Fatigue (medical) 3-hydroxyisovaleric acid Dietary Reference Intake Gluconeogenesis Heterozygous Hypotonia Histones Biotinidase Vitamin deficiencies Egg white Holocarboxylase synthetase deficiency Avidin Phenytoin Carboxylase Catabolism Urine Valproic acid Rashes Myalgia Somnolence Multiple carboxylase deficiency Paresthesias SMVT Intestinal Intestinal mucosa
Link from a Wikipage to an external page	https://www.ncbi.nlm.nih.gov/books/NBK1322/ https://www.ncbi.nlm.nih.gov/omim/253260,253260,609019,253260,609019
sameAs	Biotin deficiency Biotin deficiency Biotin deficiency Biotin deficiency Biotin deficiency
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thumbnail	wiki-commons:Special:FilePath/Biotin_structure.svg?width=300
ICD	266.200000 (xsd:double) (en) E53.8 (en)
caption	dbr:Biotin
has abstract	Biotin deficiency is a nutritional disorder which can become serious, even fatal, if allowed to progress untreated. It can occur in people of any age, ancestry, or of either sex. Biotin is part of the B vitamin family. Biotin deficiency rarely occurs among healthy people because the daily requirement of biotin is low, many foods provide adequate amounts of it, intestinal bacteria synthesize small amounts of it, and the body effectively scavenges and recycles it in the kidneys during production of urine. However, deficiencies can be caused by consuming raw egg whites over a period of weeks to months. Egg whites contain high levels of avidin, a protein that binds biotin strongly. When cooked, avidin is partially denatured and binding to biotin is reduced. However one study showed that 30-40% of the avidin activity was still present in the white after frying or boiling. Genetic disorders such as biotinidase deficiency, multiple carboxylase deficiency, and holocarboxylase synthetase deficiency can also lead to inborn or late-onset forms of biotin deficiency. In all cases – dietary, genetic, or otherwise – supplementation with biotin is the primary method of treatment. (en) Deficiência de biotina é uma condição na qual não há reservas suficientes de biotina no corpo necessárias para as atividades metabólicas normais. (pt)
eMedicineSubj	ped (en)
eMedicineTopic	238 (xsd:integer)

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