Buttermilk Creek is a tributary of the Susquehanna River in Lackawanna County and Wyoming County, in Pennsylvania, in the United States. It is approximately 6.8 miles (10.9 km) long and flows through Newton Township in Lackawanna County and Falls Township in Wyoming County. The watershed of the creek has an area of 26.1 square miles (68 km2). The creek is a perennial stream and is not designated as an impaired waterbody. Major geographical features in its watershed include the Buttermilk Falls in its lower reaches, as well as Fords Lake and Lake Winola.