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A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 β-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. Many other C2 domain families don't have calcium binding activity.

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  • C2 domain (en)
  • C2ドメイン (ja)
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  • A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 β-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. Many other C2 domain families don't have calcium binding activity. (en)
  • C2ドメイン(英: C2 domain)は、タンパク質の細胞膜への標的化に関与するタンパク質ドメインである。典型的なタイプ(PKC-C2)は8つのβストランドから構成される構造をしており、2つまたは3つのカルシウムイオンを配位する。カルシウムイオンは膜結合側に位置する、ドメインの最初と最後のループによって形成されるくぼみに結合する。一方、他のC2ドメインファミリーの多くはカルシウムイオン結合活性を持っていない。 (ja)
name
  • C2 domain (en)
  • Phosphoinositide 3-kinase C2 (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/C2dom.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1e8x_EBI.jpg
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