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About: CD82 (gene)     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : dbo:Protein, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: ThingBiomoleculegeneBiomoleculeGeneyago:WikicatClustersOfDifferentiationyago:Abstraction100002137yago:Agglomeration107959269yago:Bunch107959943yago:Collection107951464yago:Group100031264HumanGeneprotein New Facet based on Instances of this Class

CD82 (Cluster of Differentiation 82), or KAI1, is a human protein encoded by the CD82 gene. This metastasis suppressor gene product is a membrane glycoprotein that is a member of the tetraspanin/transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.