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Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2. These are unusual features for a chemokine, and allow CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine. CXCL16 is produced by dendritic cells found in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen. Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells. CXCL16 interacts with the chemokine receptor CXCR6, also known a

AttributesValues
rdf:type
rdfs:label
  • CXCL16 (en)
  • CXCL16 (de)
  • CXCL16 (uk)
rdfs:comment
  • CXCL16 (kurz für CXC-Motiv-Chemokin 16, auch Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein (SR-PSOX)) ist ein körpereigener Botenstoff, welcher der Gruppe der CXC-Motiv-Chemokine zugeordnet wird. Es besitzt zahlreiche ungewöhnliche strukturelle Eigenschaften, wodurch es sich von anderen Chemokinen unterscheidet. Es kommt sowohl in einer Zellmembran gebundenen als auch in einer löslichen Form vor. Als chemotaktisch wirkendes, das heißt die Zellbewegung steuerndes, Zytokin spielt dieses Peptid eine Rolle bei der Mobilisierung und zielgerichteten Wanderung von T-Lymphozyten. Seine Effekte vermittelt dieses Chemokin durch Bindung an den Chemokinrezeptor CXCR6. Für CXCL16 und seinen Rezeptor wird eine Rolle bei der Entstehung der Arteriosklerose angenommen. (de)
  • Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2. These are unusual features for a chemokine, and allow CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine. CXCL16 is produced by dendritic cells found in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen. Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells. CXCL16 interacts with the chemokine receptor CXCR6, also known a (en)
  • CXCL16 (англ. C-X-C motif chemokine ligand 16) – білок, який кодується однойменним геном, розташованим у людей на 17-й хромосомі. Довжина поліпептидного ланцюга білка становить 254 амінокислот, а молекулярна маса — 27 579. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk)
foaf:name
  • chemokine (C-X-C motif) ligand 16 (en)
name
  • chemokine ligand 16 (en)
dcterms:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
sameAs
dbp:wikiPageUsesTemplate
OMIM
AltSymbols
  • SCYB16, SR-PSOX, CXCLG16 (en)
symbol
  • CXCL16 (en)
UniProt
  • Q9H2A7 (en)
has abstract
  • Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2. These are unusual features for a chemokine, and allow CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine. CXCL16 is produced by dendritic cells found in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen. Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells. CXCL16 interacts with the chemokine receptor CXCR6, also known as Bonzo. Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha. The gene for human CXCL16 is located on chromosome 17. The administration of folinic acid, which forces the methylation of CXCL 16, induces high levels of methylation of the CXCL 16 gene promoter in colon, ileum and lung and causes iNKT cells accumulation in these tissues. Colonization of neonatal GF mice, but not in adult mice, with a conventional microbiota decreases hypermethylation levels of CXCL 16. (en)
  • CXCL16 (kurz für CXC-Motiv-Chemokin 16, auch Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein (SR-PSOX)) ist ein körpereigener Botenstoff, welcher der Gruppe der CXC-Motiv-Chemokine zugeordnet wird. Es besitzt zahlreiche ungewöhnliche strukturelle Eigenschaften, wodurch es sich von anderen Chemokinen unterscheidet. Es kommt sowohl in einer Zellmembran gebundenen als auch in einer löslichen Form vor. Als chemotaktisch wirkendes, das heißt die Zellbewegung steuerndes, Zytokin spielt dieses Peptid eine Rolle bei der Mobilisierung und zielgerichteten Wanderung von T-Lymphozyten. Seine Effekte vermittelt dieses Chemokin durch Bindung an den Chemokinrezeptor CXCR6. Für CXCL16 und seinen Rezeptor wird eine Rolle bei der Entstehung der Arteriosklerose angenommen. (de)
  • CXCL16 (англ. C-X-C motif chemokine ligand 16) – білок, який кодується однойменним геном, розташованим у людей на 17-й хромосомі. Довжина поліпептидного ланцюга білка становить 254 амінокислот, а молекулярна маса — 27 579. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до цитокінів. Задіяний у такому біологічному процесі, як хемотаксис. Локалізований у клітинній мембрані, мембрані.Також секретований назовні. (uk)
Arm
  • p (en)
band
Chromosome
EntrezGene
HGNCid
RefSeq
  • NM_022059 (en)
gold:hypernym
arm
  • p
band
  • 13
chromosome
  • 17
EntrezGene
  • 58191
HGNCid
  • 16642
RefSeq
  • NM_022059
UniProt
  • Q9H2A7
prov:wasDerivedFrom
page length (characters) of wiki page
OMIM id
Symbol
  • CXCL16
  • SCYB16, SR-PSOX, CXCLG16
foaf:isPrimaryTopicOf
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