About: Candidate gene     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Thing, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon
http://dbpedia.demo.openlinksw.com/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FCandidate_gene&invfp=IFP_OFF&sas=SAME_AS_OFF

The candidate gene approach to conducting genetic association studies focuses on associations between genetic variation within pre-specified genes of interest, and phenotypes or disease states. This is in contrast to genome-wide association studies (GWAS), which is a hypothesis-free approach that scans the entire genome for associations between common genetic variants (typically SNPs) and traits of interest. Candidate genes are most often selected for study based on a priori knowledge of the gene's biological functional impact on the trait or disease in question. The rationale behind focusing on allelic variation in specific, biologically relevant regions of the genome is that certain alleles within a gene may directly impact the function of the gene in question and lead to variation in th

AttributesValues
rdfs:label
  • جين مرشح (ar)
  • Kandidatengen (de)
  • Candidate gene (en)
  • Kandidaatgen (nl)
  • Ген-кандидат (ru)
rdfs:comment
  • الجينات المرشَّحَة هي جينات تخضع للدراسة في مجال الترابط الجيني من أجل تحديد صلة الترابط بين التغير الجيني لجينات محددة (يجرى ترشيحها وفق معايير محددة) وبين الأنماط الظاهرية لحالات مرضية. يختلف أسلوب الدراسة هنا عن أسلوب دراسة الترابط الجينومي الكامل (GWAS)، والذي يقوم بمسح كامل الجينوم ثم ملاحظة التغيرات الجينية. يتم ترشيح الجينات للدراسة بناءً على معرفة مسبقة للدور الوظيفي للجين المنتقى في الحالة أو الظاهرة المرضية المدروسة. (ar)
  • Als Kandidatengen (lat. candidatus = Kandidat; griech. geneá = Abstammung) werden Gene bezeichnet, die möglicherweise Assoziationen mit dem Auftreten von genetisch beeinflussten Krankheiten aufweisen. (de)
  • Ген-кандидат — ген, который может быть связан с проявлением сложного признака либо с возникновением заболевания. (ru)
  • The candidate gene approach to conducting genetic association studies focuses on associations between genetic variation within pre-specified genes of interest, and phenotypes or disease states. This is in contrast to genome-wide association studies (GWAS), which is a hypothesis-free approach that scans the entire genome for associations between common genetic variants (typically SNPs) and traits of interest. Candidate genes are most often selected for study based on a priori knowledge of the gene's biological functional impact on the trait or disease in question. The rationale behind focusing on allelic variation in specific, biologically relevant regions of the genome is that certain alleles within a gene may directly impact the function of the gene in question and lead to variation in th (en)
  • Een kandidaatgen is een gen dat zich bevindt in een chromosoomgebied dat mogelijk betrokken is bij een genetische aandoening. Wanneer dit laatste eenmaal is vastgesteld wordt van een risicogen gesproken. Om dergelijke risicovolle genen op te kunnen sporen wordt op grote schaal gebruikgemaakt van allerlei vormen van screening zoals genotypering en het analyseren van enkel-nucleotide polymorfismen. Dit gebeurt onder andere bij het bestuderen van erfelijke aandoeningen binnen families en in patiënt-controle-onderzoeken. Aan de hand van statistische toetsen worden dan vervolgens bepaalde gemiddelden berekend. Het bestuderen van de genexpressie kan vervolgens helpen de precieze rol van het gen te bepalen en bijbehorende ziektebeelden te onderscheiden. (nl)
dcterms:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
Link from a Wikipage to an external page
sameAs
dbp:wikiPageUsesTemplate
has abstract
  • الجينات المرشَّحَة هي جينات تخضع للدراسة في مجال الترابط الجيني من أجل تحديد صلة الترابط بين التغير الجيني لجينات محددة (يجرى ترشيحها وفق معايير محددة) وبين الأنماط الظاهرية لحالات مرضية. يختلف أسلوب الدراسة هنا عن أسلوب دراسة الترابط الجينومي الكامل (GWAS)، والذي يقوم بمسح كامل الجينوم ثم ملاحظة التغيرات الجينية. يتم ترشيح الجينات للدراسة بناءً على معرفة مسبقة للدور الوظيفي للجين المنتقى في الحالة أو الظاهرة المرضية المدروسة. (ar)
  • Als Kandidatengen (lat. candidatus = Kandidat; griech. geneá = Abstammung) werden Gene bezeichnet, die möglicherweise Assoziationen mit dem Auftreten von genetisch beeinflussten Krankheiten aufweisen. (de)
  • The candidate gene approach to conducting genetic association studies focuses on associations between genetic variation within pre-specified genes of interest, and phenotypes or disease states. This is in contrast to genome-wide association studies (GWAS), which is a hypothesis-free approach that scans the entire genome for associations between common genetic variants (typically SNPs) and traits of interest. Candidate genes are most often selected for study based on a priori knowledge of the gene's biological functional impact on the trait or disease in question. The rationale behind focusing on allelic variation in specific, biologically relevant regions of the genome is that certain alleles within a gene may directly impact the function of the gene in question and lead to variation in the phenotype or disease state being investigated. This approach often uses the case-control study design to try to answer the question, "Is one allele of a candidate gene more frequently seen in subjects with the disease than in subjects without the disease?" Candidate genes hypothesized to be associated with complex traits have generally not been replicated by subsequent GWASs or highly powered replication attempts. The failure of candidate gene studies to shed light on the specific genes underlying such traits has been ascribed to insufficient statistical power, low prior probability that scientists can correctly guess a specific allele within a specific gene that is related to a trait, poor methodological practices, and data dredging. (en)
  • Een kandidaatgen is een gen dat zich bevindt in een chromosoomgebied dat mogelijk betrokken is bij een genetische aandoening. Wanneer dit laatste eenmaal is vastgesteld wordt van een risicogen gesproken. Om dergelijke risicovolle genen op te kunnen sporen wordt op grote schaal gebruikgemaakt van allerlei vormen van screening zoals genotypering en het analyseren van enkel-nucleotide polymorfismen. Dit gebeurt onder andere bij het bestuderen van erfelijke aandoeningen binnen families en in patiënt-controle-onderzoeken. Aan de hand van statistische toetsen worden dan vervolgens bepaalde gemiddelden berekend. Het bestuderen van de genexpressie kan vervolgens helpen de precieze rol van het gen te bepalen en bijbehorende ziektebeelden te onderscheiden. Kandidaatgenen spelen een belangrijke rol bij het aantonen van genetische associatie. (nl)
  • Ген-кандидат — ген, который может быть связан с проявлением сложного признака либо с возникновением заболевания. (ru)
prov:wasDerivedFrom
page length (characters) of wiki page
foaf:isPrimaryTopicOf
is Link from a Wikipage to another Wikipage of
Faceted Search & Find service v1.17_git139 as of Feb 29 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software