The Captain Reuben Merrill House is an historic house at 233 West Main Street in Yarmouth, Maine. Built in 1858, it is one of the town's largest and most elaborate 19th-century houses, and is one of three known surviving works of Portland architect Thomas J. Sparrow. It was placed on the National Register of Historic Places in 1974. It is now home to Maine Preservation, a statewide architectural preservation organization.