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Cellomics is the discipline of quantitative cell analysis using bioimaging methods and informatics with a workflow involving three major components: image acquisition, image analysis, and data visualization and management. These processes are generally automated. All three of these components depend on sophisticated software to acquire qualitative data, quantitative data, and the management of both images and data, respectively. Cellomics is also a trademarked term, which is often used interchangeably with high-content analysis (HCA) or high-content screening (HCS), but cellomics extends beyond HCA/HCS by incorporating sophisticated informatics tools.