Charles Upson (March 19, 1821 – September 5, 1885) was a politician from the U.S. state of Michigan. Upson was born in Southington, Connecticut to Lydia (Webster) Upson (1781–1861) and Asahel Upson (1783–1867). He attended the district and select schools of Southington and later taught school in Farmington from 1840 to 1842. He married Sophia Upham on August 4, 1852. Charles Upson died in Coldwater and was interred in .