Cherry Run is a small unincorporated community hamlet located along the CSX Transportation (formerly Baltimore and Ohio Railroad) mainline on the Potomac River in Morgan County in the U.S. state of West Virginia. The community is named for the stream, Cherry Run, that meets the Potomac in its vicinity. It was originally known as Cherry Run Depot because of the important interchange between the B&O and the Western Maryland Railway located there. Across the Potomac from Cherry Run lies Big Pool on the Chesapeake and Ohio Canal.