Clayton-Tamm is a historic St Louis neighborhood and once an Irish-American enclave located near the western border of St. Louis, Missouri, USA, just south of Forest Park. Its borders are Hampton Avenue to the east, Manchester Road to the south, Louisville Avenue on the west and Oakland and I-64 to the north. Major growth in Cheltenham (Dogtown) defined the region in the late 19th century as it developed into a coal and clay mining community. Growth was further accelerated by preparations and construction for the 1904 World's Fair, "The Louisiana Purchase Exposition" held in nearby Forest Park.