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Clobutinol is a cough suppressant formerly distributed by Boehringer Ingelheim and its licensees under the names Lomisat and Silomat, by Bioter as Biotussin, and by Violani-Farmavigor as Pertoxil. It has been withdrawn from the market worldwide.

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  • Clobutinol (de)
  • Clobutinol (en)
  • Clobutinol (fr)
  • Clobutinol (nl)
  • Clobutinol (pt)
rdfs:comment
  • Clobutinol (ursprünglicher Handelsname: Silomat, Boehringer Ingelheim) ist ein Arzneistoff, der als Hustenstiller (Antitussivum) eingesetzt wurde. Clobutinol hemmt das Hustenzentrum im Gehirn und lindert starken Reizhusten („trockenen“ Husten). Mitte 2008 endete die Verkehrsfähigkeit für alle Clobutinol-haltigen Fertigarzneimittel, nachdem Nebenwirkungen am Herzen mit einem Risiko für lebensbedrohliche Folgen bekannt geworden waren. (siehe „“) (de)
  • Clobutinol is a cough suppressant formerly distributed by Boehringer Ingelheim and its licensees under the names Lomisat and Silomat, by Bioter as Biotussin, and by Violani-Farmavigor as Pertoxil. It has been withdrawn from the market worldwide. (en)
  • Le clobutinol (Silomat⁰) est un antitussif qui a été commercialisé en France en 1964. Il a été retiré du marché en 2011 en raison de la possibilité de survenue d'effets indésirables graves, notamment des troubles du rythme cardiaque, par allongement de l'espace QT dose-dépendant. (fr)
  • Clobutinol é um fármaco utilizado contra a tosse. Foi introduzido no mercado em 1961 e retirado do mercado pela Boehringer Ingelheim em 2007 de forma voluntária, pelos riscos coronarianos apresentados. (pt)
  • Clobutinol is een hoestmiddel (antitussivum), dat door onder de merknaam Silomat en door andere farmaceutische bedrijven verkocht werd in verschillende vormen (hoestsiroop, druppels, tabletten, injectieoplossing). Deze middelen zijn begin 2008 echter van de markt genomen in de Europese Unie, omdat het gebruik van clobutinol een verhoogd risico blijkt mee te brengen op hartritmestoornissen, meer bepaald de verlenging van het QT-interval. (nl)
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ATC suffix
  • DB03 (en)
ATC prefix
  • R05 (en)
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Cl
DrugBank
  • DB09004 (en)
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