About: Clonal hematopoiesis

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Clonal hematopoiesis of indeterminate potential, or CHIP, is a common aging-related phenomenon in which hematopoietic stem cells (HSCs) or other early blood cell progenitors contribute to the formation of a genetically distinct subpopulation of blood cells. As the name suggests, this subpopulation in the blood is characterized by a shared unique mutation in the cells' DNA; it is thought that this subpopulation is "clonally" derived from a single founding cell and is therefore made of genetic "clones" of the founder. The establishment of a clonal population may occur when a stem or progenitor cell acquires one or more somatic mutations that give it a competitive advantage in hematopoiesis over the stem/progenitor cells without these mutations. Alternatively, clonal hematopoiesis may arise w

Attributes	Values
rdfs:label	Clonal hematopoiesis (en)
rdfs:comment	Clonal hematopoiesis of indeterminate potential, or CHIP, is a common aging-related phenomenon in which hematopoietic stem cells (HSCs) or other early blood cell progenitors contribute to the formation of a genetically distinct subpopulation of blood cells. As the name suggests, this subpopulation in the blood is characterized by a shared unique mutation in the cells' DNA; it is thought that this subpopulation is "clonally" derived from a single founding cell and is therefore made of genetic "clones" of the founder. The establishment of a clonal population may occur when a stem or progenitor cell acquires one or more somatic mutations that give it a competitive advantage in hematopoiesis over the stem/progenitor cells without these mutations. Alternatively, clonal hematopoiesis may arise w (en)
foaf:depiction
dct:subject	Hematology Blood
Wikipage page ID	53925411 (xsd:integer)
Wikipage revision ID	1117108463 (xsd:integer)
Link from a Wikipage to another Wikipage	B-cell chronic lymphocytic leukemia Epigenetics Mutation Monoclonal gammopathy of undetermined significance Progenitor cell Allele frequency Cytopenia DNA Dysplasia Genetic drift Myeloproliferative neoplasm Myelodysplastic syndrome Myocardial infarction TP53 Lymphoma Stroke Haematopoiesis Hematopoietic stem cell HUMARA assay DNA (cytosine-5)-methyltransferase 3A Janus kinase 2 Acute myeloid leukemia Cardiovascular disease Digital polymerase chain reaction Hematology Hairy cell leukemia Hematology Hematopoietic stem cell transplantation ASXL1 Blood Blood cell X chromosome X-inactivation Monoclonal B-cell lymphocytosis Exon SF3B1 PPM1D Tet methylcytosine dioxygenase 2 Spliceosome Clonal expansion
sameAs	Clonal hematopoiesis Clonal hematopoiesis
dbp:wikiPageUsesTemplate	dbt:Reflist
thumbnail	wiki-commons:Special:FilePath/Clonal_Hematopoiesis_in_US_2015_Estimate.jpg?width=300
has abstract	Clonal hematopoiesis of indeterminate potential, or CHIP, is a common aging-related phenomenon in which hematopoietic stem cells (HSCs) or other early blood cell progenitors contribute to the formation of a genetically distinct subpopulation of blood cells. As the name suggests, this subpopulation in the blood is characterized by a shared unique mutation in the cells' DNA; it is thought that this subpopulation is "clonally" derived from a single founding cell and is therefore made of genetic "clones" of the founder. The establishment of a clonal population may occur when a stem or progenitor cell acquires one or more somatic mutations that give it a competitive advantage in hematopoiesis over the stem/progenitor cells without these mutations. Alternatively, clonal hematopoiesis may arise without a driving mutation, through mechanisms such as neutral drift in the stem cell population. Clonal hematopoiesis may occur in people who are completely healthy but has also been found in people with hematologic diseases. The clonal population may vary in size depending on the person, where it can be less than 2% of the blood or, at the other end, can sometimes grow close to 100%. The incidence of clonal hematopoiesis has been found to rise dramatically with age. Recent studies have demonstrated that less than 1% of the population under age 40 but approximately 10-20% of the population over age 70 has observable clonal hematopoiesis. Having clonal hematopoiesis has been linked to a more than 10-fold increased risk of developing a blood cancer, though the overall likelihood is still low. Clonal hematopoiesis does not typically give rise to noticeable symptoms, but does lead to increased risk of cardiovascular disease. (en)
prov:wasDerivedFrom	wikipedia-en:Clonal_hematopoiesis?oldid=1117108463&ns=0
page length (characters) of wiki page	41984 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Clonal_hematopoiesis
is Link from a Wikipage to another Wikipage of	Chip Myelodysplastic syndrome Haematopoiesis DNA (cytosine-5)-methyltransferase 3A Acute myeloid leukemia Cardiovascular disease Recombinant subunit vaccine Human somatic variation Cancer Likelihood in Plasma Clonal hematopoiesis of indeterminate potential CHIP (medical condition)
is Wikipage redirect of	Clonal hematopoiesis of indeterminate potential CHIP (medical condition)
is foaf:primaryTopic of	wikipedia-en:Clonal_hematopoiesis

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