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Conorfone (INN; TR-5109), also known as conorphone and codorphone, as well as conorphone hydrochloride (USAN), is an opioid analgesic that was never marketed. It is an analogue of hydrocodone substituted with an 8-ethyl group and an N-cyclopropylmethyl group. It acts as a mixed agonist-antagonist at the μ-opioid receptor, and is slightly more potent than codeine in analgesic effects but associated with somewhat greater side effects.

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  • Conorfone (en)
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  • Conorfone (INN; TR-5109), also known as conorphone and codorphone, as well as conorphone hydrochloride (USAN), is an opioid analgesic that was never marketed. It is an analogue of hydrocodone substituted with an 8-ethyl group and an N-cyclopropylmethyl group. It acts as a mixed agonist-antagonist at the μ-opioid receptor, and is slightly more potent than codeine in analgesic effects but associated with somewhat greater side effects. (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Codorphone_synthesis.svg
  • http://commons.wikimedia.org/wiki/Special:FilePath/Conorfone2DCSD.svg
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ATC prefix
  • None (en)
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  • O=C4[C@@H]5Oc1c2cCC3NCC6CC6 (en)
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  • Conorfone (INN; TR-5109), also known as conorphone and codorphone, as well as conorphone hydrochloride (USAN), is an opioid analgesic that was never marketed. It is an analogue of hydrocodone substituted with an 8-ethyl group and an N-cyclopropylmethyl group. It acts as a mixed agonist-antagonist at the μ-opioid receptor, and is slightly more potent than codeine in analgesic effects but associated with somewhat greater side effects. (en)
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CAS number
  • 72060-05-0
ChEMBL
  • 2106064
FDA UNII code
  • 9H58696D23
PubChem
  • 172964
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