The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2."
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| - Contryphan (en)
- Contrifano (it)
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| - The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2." (en)
- I contrifani sono una famiglia di peptidi che sono costituenti attivi del veleno prodotto da molluschi gasteropodi marini appartenenti al genere Conus. I due residui di amminoacidi cisteina presenti nei contrifani sono legati da un legame disolfuro. I contrifani subiscono un insolito grado di modificazioni post-traduzionali comprese l'epimerizzazione di triptofano e leucina, bromurazione del triptofano, ammidazione del C-terminale, e idrossilazione della prolina. (it)
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| - . (en)
- NMR structure of Contryphan-Vn. The peptide backbone is depicted by a curved tube while the amino acid side-chains are represented by capped sticks. Carbon atoms are colored grey, nitrogen atoms blue, oxygen atoms red, and sulfur atoms yellow. (en)
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| - The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2." (en)
- I contrifani sono una famiglia di peptidi che sono costituenti attivi del veleno prodotto da molluschi gasteropodi marini appartenenti al genere Conus. I due residui di amminoacidi cisteina presenti nei contrifani sono legati da un legame disolfuro. I contrifani subiscono un insolito grado di modificazioni post-traduzionali comprese l'epimerizzazione di triptofano e leucina, bromurazione del triptofano, ammidazione del C-terminale, e idrossilazione della prolina. (it)
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