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The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2."

AttributesValues
rdf:type
rdfs:label
  • Contryphan (en)
  • Contrifano (it)
rdfs:comment
  • The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2." (en)
  • I contrifani sono una famiglia di peptidi che sono costituenti attivi del veleno prodotto da molluschi gasteropodi marini appartenenti al genere Conus. I due residui di amminoacidi cisteina presenti nei contrifani sono legati da un legame disolfuro. I contrifani subiscono un insolito grado di modificazioni post-traduzionali comprese l'epimerizzazione di triptofano e leucina, bromurazione del triptofano, ammidazione del C-terminale, e idrossilazione della prolina. (it)
name
  • Contryphan (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/Textile_cone.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/1NXN.png
dct:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
sameAs
dbp:wikiPageUsesTemplate
thumbnail
PROSITE
  • PS60027 (en)
SCOP
caption
  • . (en)
  • NMR structure of Contryphan-Vn. The peptide backbone is depicted by a curved tube while the amino acid side-chains are represented by capped sticks. Carbon atoms are colored grey, nitrogen atoms blue, oxygen atoms red, and sulfur atoms yellow. (en)
InterPro
  • IPR011062 (en)
Pfam
  • PF02950 (en)
symbol
  • Contryphan_CS (en)
has abstract
  • The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2." (en)
  • I contrifani sono una famiglia di peptidi che sono costituenti attivi del veleno prodotto da molluschi gasteropodi marini appartenenti al genere Conus. I due residui di amminoacidi cisteina presenti nei contrifani sono legati da un legame disolfuro. I contrifani subiscono un insolito grado di modificazioni post-traduzionali comprese l'epimerizzazione di triptofano e leucina, bromurazione del triptofano, ammidazione del C-terminale, e idrossilazione della prolina. (it)
PDB
  • , , , , (en)
gold:hypernym
prov:wasDerivedFrom
page length (characters) of wiki page
Symbol
  • Contryphan_CS
foaf:isPrimaryTopicOf
is Link from a Wikipage to another Wikipage of
is foaf:primaryTopic of
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