CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed by a guanine triphosphate deoxynucleotide ("G"). The "p" refers to the phosphodiester link between consecutive nucleotides, although some ODN have a modified phosphorothioate (PS) backbone instead. When these CpG motifs are unmethylated, they act as immunostimulants. CpG motifs are considered pathogen-associated molecular patterns (PAMPs) due to their abundance in microbial genomes but their rarity in vertebrate genomes. The CpG PAMP is recognized by the pattern recognition receptor (PRR) Toll-Like Receptor 9 (TLR9), which is constitutively expressed only in B cells and plasmacytoid dendritic cells (pDCs) in humans and other higher pri
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| - CpG-Oligonukleotid (de)
- CpG oligodeoxynucleotide (en)
- CpG寡脱氧核苷酸 (zh)
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| - CpG-Oligonukleotide, auch als CpG-Oligodesoxynukleotide (CpG-ODN) bezeichnet, sind eine Klasse von einzelsträngigen synthetisch hergestellten DNA-Oligonukleotiden, die einen relativ hohen Anteil an CpG-Motiven enthalten. (de)
- CpG寡脱氧核苷酸(英語:CpG oligodeoxynucleotides,CpG ODN)是短的单链DNA分子,其序列包含一个胞嘧啶脱氧核苷酸 ("C"),紧接着一个 鳥嘌呤脱氧核苷酸 ("G"),"p"是指两者之间的磷酸二酯鍵链接。当CpG寡脱氧核苷酸处于未甲基化的状态时,可以作为。未甲基化的CpG ODN是一种病原相关分子模式,因为其在脊椎动物的基因组中很稀有,而在微生物的基因组中很丰富。。CpG ODN是公认的模式识别受体(PRR)Toll样受9(TLR9)的配体,TLR9只在人类和其他较高的灵长类动物的B细胞和浆细胞样树突状细胞(pDC)中表达。 (zh)
- CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed by a guanine triphosphate deoxynucleotide ("G"). The "p" refers to the phosphodiester link between consecutive nucleotides, although some ODN have a modified phosphorothioate (PS) backbone instead. When these CpG motifs are unmethylated, they act as immunostimulants. CpG motifs are considered pathogen-associated molecular patterns (PAMPs) due to their abundance in microbial genomes but their rarity in vertebrate genomes. The CpG PAMP is recognized by the pattern recognition receptor (PRR) Toll-Like Receptor 9 (TLR9), which is constitutively expressed only in B cells and plasmacytoid dendritic cells (pDCs) in humans and other higher pri (en)
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| - CpG-Oligonukleotide, auch als CpG-Oligodesoxynukleotide (CpG-ODN) bezeichnet, sind eine Klasse von einzelsträngigen synthetisch hergestellten DNA-Oligonukleotiden, die einen relativ hohen Anteil an CpG-Motiven enthalten. (de)
- CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed by a guanine triphosphate deoxynucleotide ("G"). The "p" refers to the phosphodiester link between consecutive nucleotides, although some ODN have a modified phosphorothioate (PS) backbone instead. When these CpG motifs are unmethylated, they act as immunostimulants. CpG motifs are considered pathogen-associated molecular patterns (PAMPs) due to their abundance in microbial genomes but their rarity in vertebrate genomes. The CpG PAMP is recognized by the pattern recognition receptor (PRR) Toll-Like Receptor 9 (TLR9), which is constitutively expressed only in B cells and plasmacytoid dendritic cells (pDCs) in humans and other higher primates. (en)
- CpG寡脱氧核苷酸(英語:CpG oligodeoxynucleotides,CpG ODN)是短的单链DNA分子,其序列包含一个胞嘧啶脱氧核苷酸 ("C"),紧接着一个 鳥嘌呤脱氧核苷酸 ("G"),"p"是指两者之间的磷酸二酯鍵链接。当CpG寡脱氧核苷酸处于未甲基化的状态时,可以作为。未甲基化的CpG ODN是一种病原相关分子模式,因为其在脊椎动物的基因组中很稀有,而在微生物的基因组中很丰富。。CpG ODN是公认的模式识别受体(PRR)Toll样受9(TLR9)的配体,TLR9只在人类和其他较高的灵长类动物的B细胞和浆细胞样树突状细胞(pDC)中表达。 (zh)
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