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About: Cyclopiazonic acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:ChemicalSubstanceType, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:Abstraction100002137yago:Agent114778436yago:Alcohol107884567yago:Beverage107881800yago:CausalAgent100007347yago:Chemical114806838yago:Compound114818238yago:Drug103247620yago:DrugOfAbuse103248958yago:Fluid114939900yago:Food100021265yago:Ketone114926294yago:Liquid114940386yago:Material114580897yago:Matter100020827yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Relation100031921yago:WikicatKetoneschemical compoundyago:Substance100019613yago:Substance100020090yago:WikicatAlcoholsumbel-rc:ChemicalSubstanceType New Facet based on Instances of this Class

Cyclopiazonic acid (α-CPA), a mycotoxin and a fungal neurotoxin, is made by the molds Aspergillus and Penicillium. It is an indole-tetramic acid that serves as a toxin due to its ability to inhibit calcium-dependent ATPases found in the endoplasmic and sarcoplasmic reticulum. This inhibition disrupts the muscle contraction-relaxation cycle and the calcium gradient that is maintained for proper cellular activity in cells.