Cytochalasins are fungal metabolites that have the ability to bind to actin filaments and block polymerization and the elongation of actin. As a result of the inhibition of actin polymerization, cytochalasins can change cellular morphology, inhibit cellular processes such as cell division, and even cause cells to undergo apoptosis. Cytochalasins have the ability to permeate cell membranes, prevent cellular translocation and cause cells to enucleate. Cytochalasins can also have an effect on other aspects of biological processes unrelated to actin polymerization. For example, and cytochalasin B can also inhibit the transport of monosaccharides across the cell membrane, has been found to regulate plant growth, cytochalasin D inhibits protein synthesis and cytochalasin E prevents angiogenesi
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| - Cytochalasine (de)
- Cytochalasin (en)
- サイトカラシン (ja)
- Citocalasina (pt)
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| - Cytochalasine sind bei vielen Pilzarten vorkommende Stoffwechselprodukte (Metabolite). In den Zellen eukaryotischer Lebewesen vermögen sie an Aktinfilamente zu binden. Dadurch wird die Polymerisation dieses Strukturproteins blockiert, in der Folge kommt es zu Änderungen der Zellgestalt (Zellmorphologie), Hemmung zellulärer Prozesse wie der Zellteilung oder sogar zum Zelltod (Apoptose). (de)
- サイトカラシン（cytochalasin）類は、アクチンフィラメントへの結合活性を有し、アクチンの重合と伸長を阻害する菌代謝物である。アクチン重合の阻害の結果、サイトカラシン類は細胞形態を変化させ、細胞分裂といった細胞過程を阻害し、アポトーシスをも引き起こす。サイトカラシン類は細胞膜を透過することができ、細胞輸送を妨げ、細胞の除核を引き起こす。また、アクチン重合とは関連のないその他の生物学的過程にも影響する。例えば、およびサイトカラシンBは細胞膜を超える単糖類の輸送を阻害し、は植物生長を調節することが明らかになっており、はタンパク質合成を阻害し、は血管新生を妨げる。 (ja)
- Citocalasina é uma substância inibidora da polimerização de filamentos de actina, análoga à colchicina, mas que actua sobre proteínas diferentes. As citocalasinas são metabolitos fúngicos que apresentam a propriedade de se ligarem aos filamentos de actina e bloquearem a sua polimerização e alongamento. A citocalasina ocorre em diferentes formas, com pequenas diferenças na sua estrutura química, designadas por citocalasinas A a J. (pt)
- Cytochalasins are fungal metabolites that have the ability to bind to actin filaments and block polymerization and the elongation of actin. As a result of the inhibition of actin polymerization, cytochalasins can change cellular morphology, inhibit cellular processes such as cell division, and even cause cells to undergo apoptosis. Cytochalasins have the ability to permeate cell membranes, prevent cellular translocation and cause cells to enucleate. Cytochalasins can also have an effect on other aspects of biological processes unrelated to actin polymerization. For example, and cytochalasin B can also inhibit the transport of monosaccharides across the cell membrane, has been found to regulate plant growth, cytochalasin D inhibits protein synthesis and cytochalasin E prevents angiogenesi (en)
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| - Cytochalasine sind bei vielen Pilzarten vorkommende Stoffwechselprodukte (Metabolite). In den Zellen eukaryotischer Lebewesen vermögen sie an Aktinfilamente zu binden. Dadurch wird die Polymerisation dieses Strukturproteins blockiert, in der Folge kommt es zu Änderungen der Zellgestalt (Zellmorphologie), Hemmung zellulärer Prozesse wie der Zellteilung oder sogar zum Zelltod (Apoptose). (de)
- Cytochalasins are fungal metabolites that have the ability to bind to actin filaments and block polymerization and the elongation of actin. As a result of the inhibition of actin polymerization, cytochalasins can change cellular morphology, inhibit cellular processes such as cell division, and even cause cells to undergo apoptosis. Cytochalasins have the ability to permeate cell membranes, prevent cellular translocation and cause cells to enucleate. Cytochalasins can also have an effect on other aspects of biological processes unrelated to actin polymerization. For example, and cytochalasin B can also inhibit the transport of monosaccharides across the cell membrane, has been found to regulate plant growth, cytochalasin D inhibits protein synthesis and cytochalasin E prevents angiogenesis. (en)
- サイトカラシン（cytochalasin）類は、アクチンフィラメントへの結合活性を有し、アクチンの重合と伸長を阻害する菌代謝物である。アクチン重合の阻害の結果、サイトカラシン類は細胞形態を変化させ、細胞分裂といった細胞過程を阻害し、アポトーシスをも引き起こす。サイトカラシン類は細胞膜を透過することができ、細胞輸送を妨げ、細胞の除核を引き起こす。また、アクチン重合とは関連のないその他の生物学的過程にも影響する。例えば、およびサイトカラシンBは細胞膜を超える単糖類の輸送を阻害し、は植物生長を調節することが明らかになっており、はタンパク質合成を阻害し、は血管新生を妨げる。 (ja)
- Citocalasina é uma substância inibidora da polimerização de filamentos de actina, análoga à colchicina, mas que actua sobre proteínas diferentes. As citocalasinas são metabolitos fúngicos que apresentam a propriedade de se ligarem aos filamentos de actina e bloquearem a sua polimerização e alongamento. A citocalasina ocorre em diferentes formas, com pequenas diferenças na sua estrutura química, designadas por citocalasinas A a J. (pt)
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