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About: DAA-1106     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatAnxiolyticsyago:Acetanilide102674912yago:Agent114778436yago:Analgesic102707683yago:CausalAgent100007347yago:Drug103247620yago:DrugOfAbuse103248958yago:Ligand115110307yago:Matter100020827yago:Medicine103740161yago:MinorTranquilizer103771443yago:PhysicalEntity100001930yago:PsychotropicAgent104017429drugyago:Sedative-hypnotic104166841yago:Sedative104166553yago:Substance100020090yago:Tranquilizer104470232yago:WikicatAcetanilidesyago:WikicatTSPOLigandsumbel-rc:DrugProduct New Facet based on Instances of this Class

DAA-1106 is a drug which acts as a potent and selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO, but with no affinity at the GABAA receptor. It has anxiolytic effects in animal studies. DAA-1106 has a sub-nanomolar binding affinity (Ki) of 0.28nM, and has been used extensively in its 3H or 11C radiolabelled form to map TSPO in the body and brain, which has proved especially helpful in monitoring the progress of neurodegenerative diseases such as Alzheimer's disease.