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DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks. DOCK family members contain a RhoGEF domain to function as guanine nucleotide exchange factors to promote GDP release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP. DOCK family proteins are categorised into four subfamilies based on their sequence homology:

AttributesValues
rdf:type
rdfs:label
  • DOCK (protein) (en)
  • DOCK (protéine) (fr)
  • DOCK蛋白家族 (zh)
rdfs:comment
  • DOCK (pour « Dedicator of cytokinesis ») est une famille de protéines intervenant dans la signalisation cellulaire et agissant comme un facteur d'échange de guanosine diphosphate en guanosine triphosphate. Elles sont classées en quatre sous familles * DOCK-A * * DOCK2 * * DOCK-B * (ou MOCA ou PBP) * * DOCK-C ou Zir * (ou Zir1) * (ou Zir2) * (ou Zir3) * DOCK-D (ou Zizimin) * (ou Zizimin1) * (ou Zizimin3) * (ou Zizimin2) (fr)
  • DOCK（Dedicator of cytokinesis 的首字母缩写）蛋白家族是一类涉及细胞内信号转导网络的蛋白质家族。DOCK家族的蛋白带有，是一种（Guanine nucleotide exchange factors，GEFs），可促使的一些（如与）释放GDP结合GTP，从而使Rho家族蛋白激活。 DOCK蛋白家族可根据其序列同源性分为以下四个亚家族： * DOCK-A 亚家族 * DOCK1（也称为 Dock180） * * * DOCK-B 亚家族 * （也称为 MOCA 或 PBP） * * DOCK-C 亚家族（也称为 Zir 亚家族） * （也称为 Zir1） * （也称为 Zir2） * （也称为 Zir3） * DOCK-D 亚家族（也称为 Zizimin 亚家族） * （也称为 Zizimin1） * （也称为 Zizimin3） * （也称为 Zizimin2） (zh)
  • DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks. DOCK family members contain a RhoGEF domain to function as guanine nucleotide exchange factors to promote GDP release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP. DOCK family proteins are categorised into four subfamilies based on their sequence homology: (en)
name
  • Dedicator of cytokinesis (en)
dct:subject
Wikipage page ID
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dbp:wikiPageUsesTemplate
SCOP
InterPro
  • IPR026791 (en)
Pfam
  • PF06920 (en)
symbol
  • Ded_cyto (en)
has abstract
  • DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks. DOCK family members contain a RhoGEF domain to function as guanine nucleotide exchange factors to promote GDP release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP. DOCK family proteins are categorised into four subfamilies based on their sequence homology: * DOCK-A subfamily * Dock180 (also known as Dock1) * Dock2 * Dock5 * DOCK-B subfamily * Dock3 (also known as MOCA and PBP) * Dock4 * DOCK-C subfamily (also known as Zir subfamily) * Dock6 (also known as Zir1) * Dock7 (also known as Zir2) * Dock8 (also known as Zir3) * DOCK-D subfamily (also known as Zizimin subfamily) * Dock9 (also known as Zizimin1) * Dock10 (also known as Zizimin3) * Dock11 (also known as Zizimin2) (en)
  • DOCK (pour « Dedicator of cytokinesis ») est une famille de protéines intervenant dans la signalisation cellulaire et agissant comme un facteur d'échange de guanosine diphosphate en guanosine triphosphate. Elles sont classées en quatre sous familles * DOCK-A * * DOCK2 * * DOCK-B * (ou MOCA ou PBP) * * DOCK-C ou Zir * (ou Zir1) * (ou Zir2) * (ou Zir3) * DOCK-D (ou Zizimin) * (ou Zizimin1) * (ou Zizimin3) * (ou Zizimin2) (fr)
  • DOCK（Dedicator of cytokinesis 的首字母缩写）蛋白家族是一类涉及细胞内信号转导网络的蛋白质家族。DOCK家族的蛋白带有，是一种（Guanine nucleotide exchange factors，GEFs），可促使的一些（如与）释放GDP结合GTP，从而使Rho家族蛋白激活。 DOCK蛋白家族可根据其序列同源性分为以下四个亚家族： * DOCK-A 亚家族 * DOCK1（也称为 Dock180） * * * DOCK-B 亚家族 * （也称为 MOCA 或 PBP） * * DOCK-C 亚家族（也称为 Zir 亚家族） * （也称为 Zir1） * （也称为 Zir2） * （也称为 Zir3） * DOCK-D 亚家族（也称为 Zizimin 亚家族） * （也称为 Zizimin1） * （也称为 Zizimin3） * （也称为 Zizimin2） (zh)
CDD
  • cd11684 (en)
gold:hypernym
prov:wasDerivedFrom
page length (characters) of wiki page
Symbol
  • Ded_cyto
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