Daniel Sharpe Malekebu (March 1, 1889 – October 8, 1978) was a doctor, Baptist missionary, and anti-colonial activist native to Nyasaland (modern Malawi). Malekebu was one of the first students of the Providence Industrial Mission founded by anti-colonial activist John Chilembwe. At the young age of fifteen, Malekebu ran away from home to seek higher education in the United States. He graduated from Meharry Medical College in 1917, becoming the first Malawian person to receive a medical degree.