About: Death effector domain

Facets (new session)
Description
Metadata
Settings
- Rule:
- Inverse Functional Properties:
- "Same As":

About: Death effector domain Goto Sponge NotDistinct Permalink

An Entity of Type : yago:WikicatProteinDomains, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon

http://dbpedia.demo.openlinksw.com/c/3RyLAEGZ8H

The death-effector domain (DED) is a protein interaction domain found only in eukaryotes that regulates a variety of cellular signalling pathways. The DED domain is found in inactive procaspases (cysteine proteases) and proteins that regulate caspase activation in the apoptosis cascade such as FAS-associating death domain-containing protein (FADD). FADD recruits procaspase 8 and procaspase 10 into a death induced signaling complex (DISC). This recruitment is mediated by a homotypic interaction between the procaspase DED and a second DED that is death effector domain in an adaptor protein that is directly associated with activated TNF receptors. Complex formation allows proteolytic activation of procaspase into the active caspase form which results in the initiation of apoptosis (cell death

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Attribute100024264 yago:Environment113934596 protein yago:Situation113927383 yago:Sphere114514039 yago:State100024720 yago:WikicatProteinDomains
rdfs:label	Death effector domain (en)
rdfs:comment	The death-effector domain (DED) is a protein interaction domain found only in eukaryotes that regulates a variety of cellular signalling pathways. The DED domain is found in inactive procaspases (cysteine proteases) and proteins that regulate caspase activation in the apoptosis cascade such as FAS-associating death domain-containing protein (FADD). FADD recruits procaspase 8 and procaspase 10 into a death induced signaling complex (DISC). This recruitment is mediated by a homotypic interaction between the procaspase DED and a second DED that is death effector domain in an adaptor protein that is directly associated with activated TNF receptors. Complex formation allows proteolytic activation of procaspase into the active caspase form which results in the initiation of apoptosis (cell death (en)
name	Death effector domain (en)
foaf:depiction
dct:subject	Protein domains
Wikipage page ID	2646715 (xsd:integer)
Wikipage revision ID	1073479396 (xsd:integer)
Link from a Wikipage to another Wikipage	Pyrin domain Procaspases Death domain Huntington's disease DNA Death-inducing signaling complex Death fold Death receptor 4 Signal transducing adaptor protein Protein–protein interaction Oligomer RNA polymerase I NF-κB Crystallization PEA15 RNA polymerase II Apoptosis Diabetes mellitus type 1 Protein kinase C CARD domain Transcription (biology) Cysteine protease Dimer (chemistry) Protease Protein domains Huntingtin Biochemical cascade Mitogen-activated protein kinase C-Jun N-terminal kinases Ca2+/calmodulin-dependent protein kinase II FAS-associating death domain-containing protein Caspase 8 Necroptosis FADD Pleiotropy N-terminus TNF receptor superfamily Huntingtin-interacting protein 1 Two-hybrid screening Phosphorylation TRAIL-R2 CD95
Link from a Wikipage to an external page	http://nashlab.bsd.uchicago.edu/index.php%3Foption=com_content&task=view&id=32&Itemid=29 http://smart.embl.de/smart/do_annotation.pl%3FDOMAIN=SM00031 http://www.fac.org.ar/fiuner/investigacion/microscopia/recep.htm http://www.ebi.ac.uk/interpro/entry/IPR001875
sameAs	Death effector domain Death effector domain Death effector domain Death effector domain Death effector domain Death effector domain Death effector domain
dbp:wikiPageUsesTemplate	dbt:Dead_link dbt:Reflist dbt:Short_description dbt:PDB2 dbt:Protein_domains dbt:Pfam_box
thumbnail	wiki-commons:Special:FilePath/PDB_1a1z_EBI.jpg?width=300
PROSITE	PS50168 (en)
SCOP	1 (xsd:integer)
SMART	DED (en)
bot	InternetArchiveBot (en)
caption	structure of the FADD death-effector domain. (en)
date	July 2019 (en)
fix-attempted	yes (en)
InterPro	IPR001875 (en)
Pfam	PF01335 (en)
symbol	DED (en)
has abstract	The death-effector domain (DED) is a protein interaction domain found only in eukaryotes that regulates a variety of cellular signalling pathways. The DED domain is found in inactive procaspases (cysteine proteases) and proteins that regulate caspase activation in the apoptosis cascade such as FAS-associating death domain-containing protein (FADD). FADD recruits procaspase 8 and procaspase 10 into a death induced signaling complex (DISC). This recruitment is mediated by a homotypic interaction between the procaspase DED and a second DED that is death effector domain in an adaptor protein that is directly associated with activated TNF receptors. Complex formation allows proteolytic activation of procaspase into the active caspase form which results in the initiation of apoptosis (cell death). Structurally the DED domain are a subclass of protein motif known as the death fold and contains 6 alpha helices, that closely resemble the structure of the Death domain (DD). (en)
CDD	cd00045 (en)
PDB	, , , , , (en)

Faceted Search & Find service v1.17_git147 as of Sep 06 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 08.03.3331 as of Sep 2 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software