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About: Demineralized bone matrix     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : dbo:Bone, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)

Type: bone New Facet based on Instances of this Class

Demineralized bone matrix (DBM) is allograft bone that has had the inorganic mineral removed, leaving behind the organic "collagen" matrix. It was first discovered by Marshall Urist in 1965 that the removal of the bone mineral exposes more biologically active bone morphogenetic proteins. These growth factors modulate the differentiation of progenitor cells into osteoprogenitor cells, which are responsible for bone and cartilage formation. As a result of the demineralization process, DBM is more biologically active than undemineralized bone grafts; conversely the mechanical properties are significantly diminished.