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Deoxyribonuclease (DNase, for short) refers to a group of glycoprotein endonucleases which are enzymes that catalyze the hydrolytic cleavage of phosphodiester linkages in the DNA backbone, thus degrading DNA. The role of the DNase enzyme in cells includes breaking down extracellular DNA (ecDNA) excreted by apoptosis, necrosis, and neutrophil extracellular traps (NET) of cells to help reduce inflammatory responses that otherwise are elicited. A wide variety of deoxyribonucleases are known and fall into one of two families (DNase I or DNase II), which differ in their substrate specificities, chemical mechanisms, and biological functions. Laboratory applications of DNase include purifying proteins when extracted from prokaryotic organisms. Additionally, DNase has been applied as a treatment f

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  • ديوكسي ريبو نوكلياز (ar)
  • Deoxyribonuclease (en)
  • DNáza (cs)
  • Desoxyribonuklease (de)
  • Desossiribonucleasi (it)
  • Désoxyribonucléase (fr)
  • デオキシリボヌクレアーゼ (ja)
  • 디옥시리보뉴클레이스 (ko)
  • Deoksyrybonukleazy (pl)
  • Desoxyribonuclease (nl)
  • Desoxirribonuclease (pt)
  • Дезоксирибонуклеаза (ru)
  • 去氧核糖核酸酶 (zh)
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  • ديوكسي ريبو نوكلياز خاصيته الكيميائية (EC 3.1.21). وهو إنزيم يعمل على تحفيز الحلمهة في عملية (إِزالة البلمرة) من (دي إن أي),والذي يختصر بصيغة (ديوكسي ريبو نوكلياز). (ar)
  • DNáza čili deoxyribonukleáza je hydrolytický enzym (tedy hydroláza a konkrétně nukleáza), který je schopen štěpit molekuly deoxyribonukleové kyseliny (DNA) na malé nebo přímo jednotlivé deoxyribonukleotidy. Enzymaticky působí DNázy na fosfodiesterových vazbách mezi sousedícími deoxyribózami. Zahrnují exodeoxyribonukleázy, které štěpí vlákno DNA pouze od kraje a endodeoxyribonukleázy, jež štěpí vlákno kdekoliv. (cs)
  • Eine Desoxyribonuklease ist ein Enzym, das die Hydrolyse von Desoxyribonukleinsäure-Molekülketten (DNA) in kürzere Molekülketten oder die Einzelbausteine katalysiert. Desoxyribonukleasen sind daher Nukleasen. (de)
  • Vengono definiti desossiribonucleasi (o anche DNasi) tutti quegli enzimi appartenenti alla classe delle transferasi che catalizzano la reazione di idrolisi dei legami fosfodiesterici dei desossiribonucleotidi, permettendo così la liberazione di . Esistono diversi tipi di desossiribonucleasi, che differiscono tra loro per il tipo di specificità per il substrato sul quale insistono. Si possono infatti riconoscere (un tipo di esonucleasi), che agiscono sulle parti terminali dei ribonucleotidi, altri invece agiscono all'interno della catena, come le (un tipo di endonucleasi). (it)
  • デオキシリボヌクレアーゼ (deoxyribonuclease, DNase) はデオキシリボ核酸のホスホジエステル結合を切断してオリゴヌクレオチドないしモノヌクレオチドに分解する一群の酵素の総称。DNase（ディーエヌアーゼ、またはディーエヌエース）とも呼ばれる。 末端から分解してゆくと内部から分解してゆくエンドヌクレアーゼに大別されるほか、3'側のホスホジエステル結合を分解するものと5'側から分解するものに分けられる。前者にはデオキシリボヌクレアーゼI（DNアーゼI、EC 3.1.21.1）などが、後者にはデオキシリボヌクレアーゼII（DNアーゼII, EC 3.1.22.1）などがある。また、特異な例として2本鎖DNAは分解しないが1本鎖DNAを分解するものも存在する。殆どあらゆる生物に存在し、DNAの代謝等に関わっている。 (ja)
  • 디옥시리보뉴클레이스(영어: deoxyribonuclease, DNase)는 DNA 골격에서 포스포다이에스터 결합의 가수분해에 의한 절단을 촉매하여 DNA를 분해하는 효소이다. 디옥시리보핵산가수분해효소, DNA 가수분해효소, DNA 분해효소라고도 한다. 디옥시리보뉴클레이스는 뉴클레이스의 한 유형으로 DNA에서 뉴클레오타이드를 연결하는 포스포다이에스터 결합을 가수분해할 수 있는 효소를 총칭한다. 기질 특이성, 화학적 메커니즘 및 생물학적 기능이 서로 다른 다양한 디옥시리보뉴클레이스가 알려져 있다. (ko)
  • A desoxirribonuclease (DNase) é uma enzima que catalisa a clivagem hidrolítica de ligações fosfodiéster na estrutura do ADN. As desoxirribonucleases são um tipo de nucleases. Uma grande variedade de desoxirribonucleases são conhecidas, que diferem na especificidade para os substratos, mecanismos químicos e funções biológicas. (pt)
  • 去氧核糖核酸酶（英語：Deoxyribonuclease；縮寫：DNase）又稱DNA酶，是指能經由水解作用，將DNA骨架上的磷酸雙酯鍵切斷的酶。DNA酶是核酸酶（nuclease）中的一種，目前已知的DNA酶有許多不同類型，主要差異在於受質專一性、化學反應機制，以及生物學上的功能。 (zh)
  • Deoxyribonuclease (DNase, for short) refers to a group of glycoprotein endonucleases which are enzymes that catalyze the hydrolytic cleavage of phosphodiester linkages in the DNA backbone, thus degrading DNA. The role of the DNase enzyme in cells includes breaking down extracellular DNA (ecDNA) excreted by apoptosis, necrosis, and neutrophil extracellular traps (NET) of cells to help reduce inflammatory responses that otherwise are elicited. A wide variety of deoxyribonucleases are known and fall into one of two families (DNase I or DNase II), which differ in their substrate specificities, chemical mechanisms, and biological functions. Laboratory applications of DNase include purifying proteins when extracted from prokaryotic organisms. Additionally, DNase has been applied as a treatment f (en)
  • La désoxyribonucléase (ou ADNase ou DNAse) est une enzyme clivant les acides désoxyribonucléiques en nucléotides ou polynucléotides. Elle hydrolyse les liaisons phosphodiester. Prenons le cas de la DNase I : cette endonucléase réalise une coupure de type a, de préférence sur les bases pyrimidiques.En présence d'ions manganèse (Mn2+), elle coupe les deux brins en bouts francs ; avec des ions magnésium (Mg2+) elle coupe un brin en petits fragments. Coupure de type a en bouts francs 5'-----'3'-OH + P-5-----3'3'-----'5'-P HO-3-----5' La réaction catalysée est la suivante : Désoxyribonucléase II (fr)
  • Desoxyribonuclease (DNase, afgekort) is een enzym en onderdeel van de groep nucleasen die de degradatie van desoxyribonucleïnezuur of DNA katalyseren. Desoxyribonuclease is een hydrolase; een enzym dat de een chemische binding genaamd fosfodi-esterbinding hydrolyseert; zonder uiteindelijk deel te nemen aan de reactie. Daarom behoort desoxyribonuclease tot de groep katalysatoren. (nl)
  • Deoksyrybonukleazy (w skrócie DNazy) – enzymy hydrolityczne z grupy nukleaz katalizujące hydrolizę łańcucha DNA na krótsze łańcuchy lub pojedyncze nukleotydy. Miejscem ataku deoksyrybonukleaz jest wiązanie fosfodiestrowe w szkielecie fosfocukrowym DNA. Do podstawowych typów znanych deoksyrybonukleaz należą DNaza I i . Deoksyrybonukleazy pochodzenia trzustkowego należą do enzymów trawiennych. (pl)
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  • ديوكسي ريبو نوكلياز خاصيته الكيميائية (EC 3.1.21). وهو إنزيم يعمل على تحفيز الحلمهة في عملية (إِزالة البلمرة) من (دي إن أي),والذي يختصر بصيغة (ديوكسي ريبو نوكلياز). (ar)
  • DNáza čili deoxyribonukleáza je hydrolytický enzym (tedy hydroláza a konkrétně nukleáza), který je schopen štěpit molekuly deoxyribonukleové kyseliny (DNA) na malé nebo přímo jednotlivé deoxyribonukleotidy. Enzymaticky působí DNázy na fosfodiesterových vazbách mezi sousedícími deoxyribózami. Zahrnují exodeoxyribonukleázy, které štěpí vlákno DNA pouze od kraje a endodeoxyribonukleázy, jež štěpí vlákno kdekoliv. (cs)
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