About: Desoxycorticosterone acetate

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Desoxycorticosterone acetate (also known as DOCA and 11-deoxycorticosterone 21-acetate and sold under the brand names Percorten Acetate and Decosterone, among others) is a mineralocorticoid medication and a mineralocorticoid ester. It is formulated as an oil solution and is administered once daily by intramuscular injection. The medication is the C21 acetate ester of 11-deoxycorticosterone.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug drug
rdfs:label	Desoxycortonacetat (de) Desoxycorticosterone acetate (en)
rdfs:comment	Desoxycorticosterone acetate (also known as DOCA and 11-deoxycorticosterone 21-acetate and sold under the brand names Percorten Acetate and Decosterone, among others) is a mineralocorticoid medication and a mineralocorticoid ester. It is formulated as an oil solution and is administered once daily by intramuscular injection. The medication is the C21 acetate ester of 11-deoxycorticosterone. (en) Desoxycortonacetat ist der Essigsäureester des Corticosteroids (11-Deoxycorticosteron) mit einer primären mineralkortikoiden Wirkung. Er wird zur Ersatztherapie des Mineralocorticoid-Mangels mit primären Hypoadrenokortizismus (Morbus Addison) angewandt. In den Nieren führt Desoxycortonacetat zur Retention von Natrium- und Chloridionen und Ausscheidung von Wasserstoff- und Kaliumionen. Dadurch entsteht ein osmotischer Gradient, der die Wasseraufnahme aus den Nierentubuli fördert und zu einer Erhöhung des Blutvolumens und der Herzleistung führt. (de)
foaf:depiction
dct:subject	Acetate esters Diketones Mineralocorticoids Pregnanes Prodrugs Progestogens Corticosteroid esters
Wikipage page ID	5142765 (xsd:integer)
Wikipage revision ID	1084540352 (xsd:integer)
Link from a Wikipage to another Wikipage	Intramuscular injection 11-deoxycorticosterone Acetate esters Diketones Mineralocorticoids Pregnanes Prodrugs Progestogens Corticosteroid Ester Mineralocorticoid Acetate Corticosteroid esters Oil solution Mineralocorticoid ester
sameAs	Desoxycorticosterone acetate Desoxycorticosterone acetate Desoxycorticosterone acetate
dbp:wikiPageUsesTemplate	dbt:Mineralocorticoids_and_antimineralocorticoids dbt:Drugbox dbt:Mineralocorticoid_receptor_modulators dbt:Progesterone_receptor_modulators dbt:Reflist dbt:Short_description dbt:Steroid-stub
thumbnail	wiki-commons:Special:FilePath/Desoxycorticosterone_acetate.svg?width=300
c	23 (xsd:integer)
CAS number	56 (xsd:integer)
ChEBI	34671 (xsd:integer)
ChEMBL	1200542 (xsd:integer)
ChemSpiderID	5737 (xsd:integer)
class	Corticosteroid Mineralocorticoid
DrugBank	DB06780 (en)
H	32 (xsd:integer)
IUPAC name	[2-[-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate (en)
KEGG	D03698 (en)
O	4 (xsd:integer)
PubChem	5952 (xsd:integer)
routes of administration	Intramuscular injection
SMILES	CCOCC[C@H]1CC[C@@H]2[C@@]1C (en)
StdInChI	1 (xsd:integer)
StdInChIKey	VPGRYOFKCNULNK-ACXQXYJUSA-N (en)
synonyms	DOCA; 11-Deoxycorticosterone 21-acetate; 21-Acetoxypregn-4-ene-3,20-dione (en)
tradename	Percorten Acetate, Decosterone, others (en)
UNII	6 (xsd:integer)
has abstract	Desoxycorticosterone acetate (also known as DOCA and 11-deoxycorticosterone 21-acetate and sold under the brand names Percorten Acetate and Decosterone, among others) is a mineralocorticoid medication and a mineralocorticoid ester. It is formulated as an oil solution and is administered once daily by intramuscular injection. The medication is the C21 acetate ester of 11-deoxycorticosterone. (en) Desoxycortonacetat ist der Essigsäureester des Corticosteroids (11-Deoxycorticosteron) mit einer primären mineralkortikoiden Wirkung. Er wird zur Ersatztherapie des Mineralocorticoid-Mangels mit primären Hypoadrenokortizismus (Morbus Addison) angewandt. In den Nieren führt Desoxycortonacetat zur Retention von Natrium- und Chloridionen und Ausscheidung von Wasserstoff- und Kaliumionen. Dadurch entsteht ein osmotischer Gradient, der die Wasseraufnahme aus den Nierentubuli fördert und zu einer Erhöhung des Blutvolumens und der Herzleistung führt. (de)
prov:wasDerivedFrom	wikipedia-en:Desoxycorticosterone_acetate?oldid=1084540352&ns=0
page length (characters) of wiki page	3431 (xsd:nonNegativeInteger)
alternative name	Percorten Acetate, Decosterone, others (en)
CAS number	56-47-3
ChEBI	34671
ChEMBL	1200542
DrugBank	DB06780
FDA UNII code	6E0A168OB8
KEGG	D03698
PubChem	5952
class	Corticosteroid Mineralocorticoid
foaf:isPrimaryTopicOf	wikipedia-en:Desoxycorticosterone_acetate
is Link from a Wikipage to another Wikipage of	Percorten Acetate Percorten acetate Decosterone DOCA Desoxycortone 21-acetate Desoxycortone acetate 11-Deoxycorticosterone acetate 11-deoxycorticosterone acetate Deoxycorticosterone acetate
is Wikipage redirect of	Percorten Acetate Percorten acetate Decosterone DOCA Desoxycortone 21-acetate Desoxycortone acetate 11-Deoxycorticosterone acetate 11-deoxycorticosterone acetate Deoxycorticosterone acetate
is foaf:primaryTopic of	wikipedia-en:Desoxycorticosterone_acetate

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