Destanni Mone Henderson (born February 2, 1999) is an American professional basketball player for the Indiana Fever of the Women's National Basketball Association (WNBA). Henderson played college basketball for the South Carolina Gamecocks, helping her team win the national championship and earning first-team All-Southeastern Conference honors as a senior. At Fort Myers Senior High School, she won three straight state titles, was a McDonald's All-American selection and was rated as the number one point guard in her class by ESPN. Henderson competes for the United States national team and won a gold medal at the 2021 FIBA AmeriCup.