Class 2 dihydroorotate dehydrogenases (DHOQO, EC 1.3.5.2) is an enzyme with systematic name (S)-dihydroorotate:quinone oxidoreductase. This enzyme catalyses the electron transfer from dihydroorotate (electron donor) to a quinone (electron acceptor): (S)-dihydroorotate + quinone orotate + quinol
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| - Dihydroorotate dehydrogenase (quinone) (en)
- ジヒドロオロト酸デヒドロゲナーゼ (キノン) (ja)
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| - ジヒドロオロト酸デヒドロゲナーゼ (キノン)(dihydroorotate dehydrogenase (quinone), DHOD, DHODH)は、ジヒドロオロト酸デヒドロゲナーゼのうちキノンを電子受容体とするもの(クラス2)である。ピリミジンのde novo合成の4番目の化学反応を触媒する酸化還元酵素であり、補因子としてFMNを結合するフラボタンパク質である。 (ja)
- Class 2 dihydroorotate dehydrogenases (DHOQO, EC 1.3.5.2) is an enzyme with systematic name (S)-dihydroorotate:quinone oxidoreductase. This enzyme catalyses the electron transfer from dihydroorotate (electron donor) to a quinone (electron acceptor): (S)-dihydroorotate + quinone orotate + quinol (en)
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| - Dihydroorotate:quinone oxidoreductase (en)
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| - Dihydroorotate:quinone oxidoreductase (en)
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| - Class 2 dihydroorotate dehydrogenases (DHOQO, EC 1.3.5.2) is an enzyme with systematic name (S)-dihydroorotate:quinone oxidoreductase. This enzyme catalyses the electron transfer from dihydroorotate (electron donor) to a quinone (electron acceptor): (S)-dihydroorotate + quinone orotate + quinol These enzymes differ from class 1 dihydroorotate dehydrogenases (DHODH) on the electron acceptor, on their structure, and on their cellular localization. Since the reaction catalyzed by DHOQOs is both part of the electron transport chain and the pyrimidine de novo synthesis, it has been explored as a possible target for cancer treatment, immunological disorders and bacterial/viral infections. (en)
- ジヒドロオロト酸デヒドロゲナーゼ (キノン)(dihydroorotate dehydrogenase (quinone), DHOD, DHODH)は、ジヒドロオロト酸デヒドロゲナーゼのうちキノンを電子受容体とするもの(クラス2)である。ピリミジンのde novo合成の4番目の化学反応を触媒する酸化還元酵素であり、補因子としてFMNを結合するフラボタンパク質である。 (ja)
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